Spinal 5-HT-receptors and tonic modulation of transmission through a withdrawal reflex pathway in the decerebrated rabbit

British Journal of Pharmacology
R W ClarkeA K Houghton

Abstract

1. In decerebrated, non-spinalized rabbits, intrathecal administration of either of the selective 5-HT1A-receptor antagonists (S)WAY-100135 or WAY-100635 resulted in dose-dependent enhancement of the reflex responses of gastrocnemius motoneurones evoked by electrical stimulation of all myelinated afferents of the sural nerve. The approximate ED50 for WAY-100635 was 0.9 nmol and that for (S)WAY-100135 13 nmol. Intrathecal doses of the antagonists which caused maximal facilitation of reflexes in non-spinalized rabbits had no effect in spinalized preparations. 2. In non-spinalized animals, intravenous administration of (S)WAY-100135 was significantly less effective in enhancing reflexes than when it was given by the intrathecal route. 3. When given intrathecally, the selective 5-HT 2A/2C-receptor antagonist, ICI 170,809, produced a bellshaped dose-effect curve, augmenting reflexes at low doses (< or = 44 nmol), but reducing them at higher doses (982 nmol). Idazoxan, the selective alpha 2-adrenoceptor antagonist, was less effective in enhancing reflex responses when given intrathecally after ICI 170,809 compared to when it was given alone. Intravenous ICI 170,809 resulted only in enhancement of reflexes and the facilitatory effects...Continue Reading

References

Jan 1, 1991·Annual Review of Neuroscience·H L FieldsP Mason
Jul 1, 1991·British Journal of Pharmacology·H Crick, D I Wallis
Feb 1, 1991·Canadian Journal of Physiology and Pharmacology·L Zhang
Nov 1, 1990·The Journal of Physiology·M Y Wang, N J Dun
Jun 12, 1990·European Journal of Pharmacology·I van WijngaardenW Soudijn
Feb 19, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A W Duggan
Oct 1, 1988·The Journal of Physiology·R W ClarkeJ S Taylor
Jun 1, 1988·British Journal of Pharmacology·A ButlerM B Tyers
Jan 1, 1988·Progress in Brain Research·A W Duggan, C R Morton
Jan 1, 1988·Progress in Brain Research·F P ZemlanR M Murphy
Jan 1, 1968·Acta Physiologica Scandinavica·I EngbergR W Ryall
Jan 1, 1982·Progress in Brain Research·R M BowkerJ D Coulter
May 1, 1995·The Journal of Comparative Neurology·N M KheckE C Azmitia
Jun 24, 1993·European Journal of Pharmacology·A FletcherY Reilly
Jul 25, 1995·European Journal of Pharmacology·E A ForsterA Fletcher
Jan 1, 1996·Behavioural Brain Research·C Routledge
Feb 5, 1996·The Journal of Comparative Neurology·H K KiaD Vergé
Jan 1, 1964·Acta Physiologica Scandinavica·A CARLSSONN A HILLARP
Jun 20, 1964·Nature·N E ANDENA LUNDBERG

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Citations

Mar 18, 1999·Pharmacology, Biochemistry, and Behavior·D L MendozaH H Swanson
Nov 15, 2002·Neuroscience Letters·Gonzalo HedoJose A Lopez-Garcia
Apr 29, 1998·British Journal of Pharmacology·J Ogilvie, R W Clarke
Jul 8, 2000·Neuropharmacology·R W ClarkeJ Ogilvie
May 29, 2014·Journal of Neural Transmission·Raffaele NardoneEugen Trinka
Apr 8, 2004·Journal of Neurophysiology·D J BennettM A Gorassini
Oct 3, 2001·Physiological Reviews·S C Gandevia
Aug 15, 2002·CNS Drug Reviews·R W Clarke, J Harris
Jun 30, 2018·Biology of Sex Differences·Aude-Clémence M DoixPeter A Federolf
Feb 6, 2020·Frontiers in Cellular Neuroscience·Yann Develle, Hugues Leblond

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