Jun 1, 1976

Spinal adrenergic mechanisms regulating sympathetic outflow to blood vessels

Circulation Research
D G Taylor, M J Brody

Abstract

The role of descending spinal catecholamine (CA)-containing fibers in cardiovascular regulation was examined. Monoamine-containing fibers were visualized by fluorescence histochemical methods at the cervical, thoracic, and lumbar spinal segments. Two major groups of descending CA-containing axons were located in the lateral funiculus at the midcervical spinal level. At the thoracolumbar spinal segments CA-containing terminals were concentrated mostly around cells of the intermediolateral nucleus. In addition a distinct CA-containing fasciculus was observed at the level of the sympathetic nucleus which appeared to course toward the opposite site of the cord. To evaluate the role of the efferent CA-containing fibers, changes in heart rate, arterial pressure, femoral blood flow, and calculated peak vascular resistance were elicited by electrical stimulation of selected sites in the midcervical spinal cord. Although changes in femoral flow and arterial pressure were evoked from many midcervical sites, there was a distinct correlation between the magnitude of peak femoral resistance elevation and density of CA-containing axons activated. Furthermore, efferent spinal vasoconstrictor outflow to the hindlimbs crosses below the cervical...Continue Reading

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Mentioned in this Paper

Arterial Pulse Pressure
Gallamine
Z-Max
Biochemical Pathway
Blood Flow Velocity
Catecholamine [EPC]
Vascular Resistance
Vasomotor System
Lateral Funiculus
Entire Spinal Subarachnoid Space

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