'Spinal amaurosis' (1841). On the early contribution of Edward Hocken to the concept of neuromyelitis optica

Journal of Neurology
S Jarius, B Wildemann

Abstract

While the history of classical multiple sclerosis has been extensively studied, only little is known about the early history of neuromyelitis optica (Devic's syndrome). Here we discuss a forgotten report by Edward Octavius Hocken (1820-1845) published in The Lancet in 1841. Hocken's report is important from a historic point of view for two reasons. Firstly, apart from a French language report by Antoine Portal, no earlier case of spinal cord inflammation and amaurosis is known. Secondly and much more importantly, Hocken, who upon his untimely death at the age of just 25 years was honoured by his contemporaries as a "precocious talent" of "very early reputation", in that article propagated the novel concept of 'spinal amaurosis', i.e. the concept of acute amaurosis and spinal cord disease being pathogenetically connected. Hocken's ideas predate Devic and Gault's seminal works on 'neuromyelitis optica' by more than 50 years.

References

Sep 25, 1999·Neurology·D M WingerchukB G Weinshenker
Jan 1, 1958·Medical History·R A HUNTER, J L THORNTON
Aug 10, 2005·The Journal of Experimental Medicine·Vanda A LennonShannon R Hinson
Aug 21, 2007·Lancet Neurology·Dean M WingerchukBrian G Weinshenker
Mar 13, 2008·Nature Clinical Practice. Neurology·Sven JariusBrigitte Wildemann
Oct 27, 2009·Journal of Autoimmunity·Johann SellnerMark Mühlau
Jun 10, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J SellnerB Hemmer
Jul 20, 2010·Nature Reviews. Neurology·Sven Jarius, Brigitte Wildemann
Oct 19, 2010·Journal of Neurology·Gulsen Akman-DemirMefkure Eraksoy
May 6, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Sven JariusBrigitte Wildemann
Jun 22, 2011·Multiple Sclerosis : Clinical and Laboratory Research·S Jarius, B Wildemann
Oct 14, 2011·Journal of the Neurological Sciences·S Jarius, B Wildemann
Dec 6, 2011·Clinical Neurology and Neurosurgery·S JariusB Wildemann
Jul 26, 2012·Multiple Sclerosis : Clinical and Laboratory Research·K-H ChangL-S Ro
Oct 6, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Satoshi YoshimuraUNKNOWN South Japan Multiple Sclerosis Genetics Consortium
Nov 13, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yang YangQian Wu
Dec 22, 2012·Multiple Sclerosis : Clinical and Laboratory Research·K RostásyM Reindl
Jan 17, 2013·Journal of Neuroinflammation·Sven Jarius, Brigitte Wildemann
Feb 26, 2013·BMJ : British Medical Journal·Sven Jarius, Brigitte Wildemann
Nov 26, 2013·Journal of Neurology·Corinna TrebstUNKNOWN Neuromyelitis Optica Study Group (NEMOS)

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Citations

Aug 26, 2015·Journal of the Neurological Sciences·S Jarius, B Wildemann
Mar 29, 2014·Clinical and Experimental Immunology·S JariusF Paul
Apr 21, 2020·Expert Review of Neurotherapeutics·Mattia RossoTanuja Chitnis
Dec 31, 2019·Journal of Neuroinflammation·S Jarius, B Wildemann

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