PMID: 7034758Jan 1, 1982Paper

Spinal anaesthesia with hyperbaric bupivacaine: effects of concentration and volume administered

British Journal of Anaesthesia
W A ChambersD B Scott

Abstract

A double-blind study was carried out using hyperbaric solutions of bupivacaine to compare the effects of varying the concentration of bupivacaine and the volume of solution administered intrathecally. Fifty-seven patients were studied. Ten patients received each volume of each concentration: 0.5% bupivacaine in 8% dextrose, 2 ml, 3 ml or 4 ml and 0.75% bupivacaine in 8% dextrose, 1.3 ml or 2 ml. A further seven patients received 3 ml of the 0.75% solution. Both solutions consistently produced good nerve blockade. With the 0.5% solution, increases in the volume administered had no effect on the spread of sensory loss, whereas with the 0.75% solution, increasing the volume administered resulted in a significantly greater cephalad spread. The use of 3 ml of this solution was abandoned after seven patients had received it because of the excessive spread. With both solutions, increasing the volume produced a longer duration of action. The use of a 0.75% solution of hyperbaric bupivacaine for spinal anaesthesia did not appear to confer any advantage over the 0.5% solution.

Citations

May 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J A Wildsmith
Jun 2, 2000·Regional Anesthesia and Pain Medicine·D H ChoiM H Kim
May 23, 2002·Regional Anesthesia and Pain Medicine·Ian F Russell
Jan 1, 1991·Acta Anaesthesiologica Scandinavica·M Tuominen
Aug 1, 1991·Acta Anaesthesiologica Scandinavica·E SlothI Zülow
Oct 1, 1993·Acta Anaesthesiologica Scandinavica·G GaggeroZ Gamulin
May 1, 1995·Acta Anaesthesiologica Scandinavica·H M PoveyJ Jacobsen
Apr 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E F Van GesselZ Gamulin
Jun 1, 1983·Acta Anaesthesiologica Scandinavica·M BengtssonJ B Löfström
Feb 1, 1987·Acta Anaesthesiologica Scandinavica·A SundbergL Wiklund
May 1, 1989·Anaesthesia·T M Gallagher, P M Crean
May 25, 2004·Anesthesia and Analgesia·Michela CamorciaMalachy O Columb
Oct 1, 1996·Anesthesia and Analgesia·B Ben-DavidS Vaida
Jun 1, 1987·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M T LaroccoR J Mandle

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