Spinal Anaplastic Oligodendroglioma With Oligodendrogliomatosis: Molecular Markers and Management: Case Report

Neurosurgery
Ben A StricklandJeffrey S Weinberg

Abstract

Spinal cord oligodendrogliomas are rare tumors, with a reported incidence varying between 0.8% and 4.7% of all spinal cord tumors and just over 50 cases reported in the literature. Of these, only 9 cases are histologically defined as anaplastic oligodendrogliomas, with few having complete molecular characterization. The diffuse tumor spread that can occur along the subarachnoid space with secondary invasion of the leptomeninges is called oligodendrogliomatosis and is associated with poor outcome. A 68-year-old man with a history of lumbar stenosis status after lumbar decompression presented with new-onset right lower-extremity weakness. Magnetic resonance imaging demonstrated an intramedullary lesion from T9 to T12. During an attempted diagnostic biopsy, numerous intradural intramedullary lesions not present on magnetic resonance imaging were observed. Tissue biopsy demonstrated a 1p/19q-codeleted anaplastic oligodendroglioma with diffuse oligodendrogliomatosis. Postoperative treatment included 39.2-Gy radiation over 22 fractions from T1 to the bottom of the thecal sac with a boost to the T9-T12 area, the primary site of disease, to a total dose of 43.2 Gy in 24 fractions, followed by adjuvant temozolomide at a dose of 200 mg/m...Continue Reading

References

Oct 1, 1995·Journal of Neurosurgery·R ChenD A Ramsay
Jan 1, 1995·Neurosurgery·L R RogersL Harrold
Apr 1, 1993·Journal of Korean Medical Science·K C WangB K Cho
May 14, 1998·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D H NamK C Wang
Jun 28, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J van den BentUNKNOWN European Organization for Research and Treatment of Cancer Brain Tumor Group
Aug 1, 1951·A.M.A. Archives of Neurology and Psychiatry·J G LOVEH W WOLTMAN
May 13, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kostas N FountasJoe Sam Robinson
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Intergroup Radiation Therapy Oncology Group Trial 9402Walter Curran
Jul 21, 2006·Journal of Neuro-oncology·A Taliansky-AronovT Siegal
Nov 2, 2006·Journal of Neuro-oncology·Ayca OzkulAli Akyol
Apr 18, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C RamirezS Blond
Mar 18, 2009·Journal of Neuro-oncology·Marlon S MathewsRonald C Kim
Jun 30, 2009·Journal of Neurosurgery. Spine·Kern H GuppyMichael D Prados
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc SansonJean-Yves Delattre
Feb 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin J van den BentMarc Sanson
Apr 30, 2010·Neurology·M LabussièreM Sanson
Jul 10, 2012·Acta Neuropathologica·Benjamin EllezamKenneth D Aldape
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin J van den BentKhê Hoang-Xuan
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory CairncrossMinesh Mehta
Feb 12, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Gregory CairncrossWalter J Curran
Apr 8, 2015·Nature Genetics·Hiromichi SuzukiSeishi Ogawa

❮ Previous
Next ❯

Citations

Feb 7, 2016·The Spine Journal : Official Journal of the North American Spine Society·Jeng-Hung GuoDer-Yang Cho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Brain Tumor Research and Treatment
Ju Hyung MoonJong Hee Chang
Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes
Sabrina CovertAshok Modha
Journal of Neuro-oncology
Marlon S MathewsRonald C Kim
Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Mishal Mendiratta-LalaRajan Jain
© 2021 Meta ULC. All rights reserved