Spinal anesthesia with meperidine. Effects of added alpha-adrenergic agonists: epinephrine versus clonidine

Anesthesia and Analgesia
I AcalovschiC Manoiu

Abstract

We determined the effects of intrathecally administered epinephrine and clonidine on the duration and quality of a meperidine spinal block. Forty-five patients scheduled for orthopedic surgery, divided into three groups, received spinal anesthesia with 1 mg/kg 5% meperidine, alone or with 200 microg epinephrine or 2 microg/kg clonidine. Using a double-blind method, the onset, extension, and duration of sensory block (to pinprick) and the duration and degree of motor block (Bromage scale) were assessed. Hemodynamic responses, duration of postoperative analgesia, degree of sedation, and occurrence of side effects were also recorded. The addition of epinephrine to the meperidine solution prolonged the sensory block (P<0.01) but did not affect its onset or extent. A similar potentiating effect was demonstrated for clonidine (P<0.001). The duration and degree of motor block were increased by addition of both epinephrine and clonidine. A tendency toward bradycardia and a decrease of mean arterial pressure was potentiated by clonidine but not by the epinephrine. Only the addition of clonidine prolonged the postoperative analgesia (P<0.001), but was associated with an increased sedation score. The incidence of other side effects did no...Continue Reading

References

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Citations

Dec 31, 2004·Current Pain and Headache Reports·James W Heitz, Eugene R Viscusi
Oct 12, 2010·Saudi Journal of Anaesthesia·Sukhminder Jit Singh BajwaJasbir Kaur
Mar 8, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Shiv Kumar RaghuwanshiVishal Bankwar
Jul 28, 2012·International Journal of Critical Illness and Injury Science·Sukhminder Jit Singh BajwaSurjit Singh Parmar
Jan 1, 2010·Anesthesia, Essays and Researches·Sukhminder Jit Singh BajwaAparajita Panda
Jul 26, 2002·Acta Anaesthesiologica Scandinavica·I DobrydnjovB Holmström
Jan 29, 2003·Anesthesiology·Alain BorgeatCarlo A Schenker

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