Abstract
We determined the effects of intrathecally administered epinephrine and clonidine on the duration and quality of a meperidine spinal block. Forty-five patients scheduled for orthopedic surgery, divided into three groups, received spinal anesthesia with 1 mg/kg 5% meperidine, alone or with 200 microg epinephrine or 2 microg/kg clonidine. Using a double-blind method, the onset, extension, and duration of sensory block (to pinprick) and the duration and degree of motor block (Bromage scale) were assessed. Hemodynamic responses, duration of postoperative analgesia, degree of sedation, and occurrence of side effects were also recorded. The addition of epinephrine to the meperidine solution prolonged the sensory block (P<0.01) but did not affect its onset or extent. A similar potentiating effect was demonstrated for clonidine (P<0.001). The duration and degree of motor block were increased by addition of both epinephrine and clonidine. A tendency toward bradycardia and a decrease of mean arterial pressure was potentiated by clonidine but not by the epinephrine. Only the addition of clonidine prolonged the postoperative analgesia (P<0.001), but was associated with an increased sedation score. The incidence of other side effects did no...Continue Reading
References
Aug 1, 1992·Anesthesiology·K S FilosV Polyzou
Jan 1, 1991·Anesthesiology·T KauppilaA Pertovaara
Jan 1, 1991·Anesthesiology·P L BaileyT H Stanley
Dec 1, 1990·Anesthesiology·M H OssipovJ Bagley
Sep 1, 1990·Anesthesiology·A M MalinowR A Howard
Dec 1, 1990·Anesthesiology·G CrosbyK R Davies
May 1, 1989·Anesthesia and Analgesia·F BonnetC Touboul
May 1, 1987·Anesthesia and Analgesia·J P RacleB Gleizal
Sep 1, 1986·British Journal of Anaesthesia·I AcalovschiF Nicolaus
Jan 1, 1986·Upsala Journal of Medical Sciences·T Gordh, P Hartvig
Mar 1, 1987·Anesthesiology·R C Roy
May 1, 1985·Anesthesia and Analgesia·D L Spivey
Jun 22, 1974·British Medical Journal·M A RamsayR Goodwin
Jan 1, 1982·Annales Françaises D'anesthèsie Et De Rèanimation·N MirceaA Leoveanu
Jan 29, 1981·European Journal of Pharmacology·P BousquetJ Schwartz
Oct 1, 1994·Acta Anaesthesiologica Scandinavica·L Niemi
Oct 1, 1994·Pain·Philip J SiddallMichael J Cousins
May 1, 1994·Acta Anaesthesiologica Scandinavica·L NiemiP H Rosenberg
Nov 1, 1993·British Journal of Anaesthesia·D J FogartyK R Milligan
Nov 1, 1993·British Journal of Anaesthesia·P A StoneD A Jarvis
Feb 1, 1993·Anaesthesia and Intensive Care·M J Paech
Apr 1, 1993·Anaesthesia·D J Bihari, R W Chang
Citations
Dec 31, 2004·Current Pain and Headache Reports·James W Heitz, Eugene R Viscusi
May 23, 2012·Regional Anesthesia and Pain Medicine·Gildasio S de OliveiraRobert J McCarthy
Oct 12, 2010·Saudi Journal of Anaesthesia·Sukhminder Jit Singh BajwaJasbir Kaur
Mar 16, 2013·Journal of Anaesthesiology, Clinical Pharmacology·Anil ThakurSusheela Taxak
Mar 8, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Shiv Kumar RaghuwanshiVishal Bankwar
Jul 28, 2012·International Journal of Critical Illness and Injury Science·Sukhminder Jit Singh BajwaSurjit Singh Parmar
Jan 1, 2010·Anesthesia, Essays and Researches·Sukhminder Jit Singh BajwaAparajita Panda
Apr 2, 2015·Saudi Journal of Anaesthesia·Jayashree Sen, Bitan Sen
Oct 18, 2016·Anesthesia, Essays and Researches·Major Vishal AroraArindam Sarkar
Dec 30, 2017·Anesthesia, Essays and Researches·Mahendra SinghDevendra Negi
Jul 26, 2002·Acta Anaesthesiologica Scandinavica·I DobrydnjovB Holmström
Apr 23, 2003·Anesthesia and Analgesia·I DobrydnjovA Gupta
Mar 23, 2007·Anesthesia and Analgesia·Ali MovafeghNiloufar Akbarian-Tefaghi
May 31, 2001·Anesthesiology·M De KockP Lavand'homme
Jan 29, 2003·Anesthesiology·Alain BorgeatCarlo A Schenker