Spinal cord atrophy in multiple sclerosis and relationship with disability across clinical phenotypes

Multiple Sclerosis and Related Disorders
Evanthia BernitsasOmar Khan

Abstract

Several studies have shown a relationship between spinal cord atrophy and clinical disability in patients with multiple sclerosis (MS). We examined the correlation between cervical cord cross-sectional area at the C2 vertebral level (CSA-C2) and the expanded disability status scale (EDSS) in patients with relapsing-remitting and progressive forms of MS. The latter included both secondary and primary progressive MS patients. A total of 150 patients with MS were recruited from the Wayne State University MS clinic. Ninety-three had relapsing-remitting MS and 57 patients had progressive MS. MRI scan of the cervical cord was obtained for each patient. Correlation studies and multivariate regression analysis was performed, blinded to clinical status. The mean age was 41.3 year old, 64.6% were women, mean disease duration was 11.2 years, CSA-C2 was 80.2mm(2) and mean EDSS was 3.8. There was significant correlation between CSA-C2 and EDSS (r -0.75, p<0.0001). Sub-group analysis showed CSA-C2 was 68.6mm(2) and 87.3mm(2) in the progressive and relapsing-remitting groups, respectively (p<0.0001). Multivariable regression showed that CSA-C2 was a significant predictor of disability independent of disease duration, and phenotype. Our study ...Continue Reading

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Citations

Jul 28, 2016·Multiple Sclerosis and Related Disorders·Yanqiang WangZhengqi Lu
Mar 22, 2018·Current Opinion in Neurology·Matilde Inglese, Maria Petracca
Apr 13, 2017·Brain Pathology·Natalia PetrovaKlaus Schmierer
Aug 5, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kedar R Mahajan, Daniel Ontaneda
Aug 14, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Courtney CasserlyJiwon Oh
Jun 29, 2018·Neurology·Charidimos TsagkasKatrin Parmar
Apr 21, 2020·Expert Review of Neurotherapeutics·Eleonora TavazziNiels Bergsland
Jun 21, 2020·International Journal of Molecular Sciences·Madeline BrossEvanthia Bernitsas
Nov 19, 2020·Brain Sciences·Yongsheng ChenEvanthia Bernitsas
Jun 18, 2019·Journal of the Neurological Sciences·Jonathan ZurawskiRohit Bakshi
Oct 19, 2020·Revue neurologique·S LeguyA Kerbrat
Nov 21, 2021·Acta Neurologica Scandinavica·Asta TheodorsdottirMads Henrik Ravnborg

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