PMID: 9427170Jan 14, 1998Paper

Spinal cord compression by heterotopic ossification associated with pseudohypoparathyroidism

The Journal of International Medical Research
Y YamamotoH Kida

Abstract

This report describes a 37-year-old man presenting with a gait disturbance due to spastic paraparesis. Physical findings showed typical features of Albright's hereditary osteodystrophy, including short stature, obesity, brachydactyly and dental hypoplasia. He was diagnosed as having pseudohypoparathyroidism type Ia, on the basis of his hypocalcaemia, hyperphosphataemia, increased plasma level of parathyroid hormone (PTH), and the unresponsiveness to exogenous PTH loading of his urinary excretion of both nephrogenous cyclic adenosine monophosphate and phosphate. Magnetic resonance imaging and myelographic computed tomographic scans clearly demonstrated severe compression of the spinal cord at T 9/10 by tumour-like ossifications of the paravertebral ligaments. Neurosurgical decompression therapy was, therefore, performed to alleviate his spastic paraparesis. This was a rare case of pseudohypoparathyroidism complicated with spinal cord compression caused by ectopic ossification of the ligaments.

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Citations

Apr 30, 2010·The Journal of Clinical Endocrinology and Metabolism·M LebrunM L Kottler
Mar 5, 2021·Annals of the New York Academy of Sciences·Xiaoping TanLina Pei

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