Spinal cord gray matter layers rich in NADPH diaphorase-positive neurons are refractory to ischemia-reperfusion-induced injury: a histochemical and silver impregnation study in rabbit

Experimental Neurology
J MarsalaM Marsala

Abstract

Silver impregnation analysis of neuronal damage and concurrent histochemical characterization of NADPH diaphorase-positive neuronal pools in the rabbit lumbosacral segments was performed during and after transient spinal cord ischemia. Strongly enhanced staining of NADPH diaphorase-positive neurons and their processes appeared in the superficial dorsal horn (laminae I-III), the pericentral region (lamina X) of lower lumbar segments, the lateral collateral pathway, and mainly in neurons of the sacral parasympathetic nucleus in the S2 segment at the end of 40 min of abdominal aorta ligation or 1 day after reperfusion. Despite the development of extensive neuronal degeneration in the central gray matter (laminae IV-VII) between 1 and 4 days after ischemia, a number of nonnecrotizing neurons localized in the areas corresponding with the distribution of NADPH diaphorase-positive neurons was detected, suggesting a selective resistance of these classes of neurons against transient ischemic insult. While the precise mechanism of the observed resistance is not known, it is postulated that region-specific synthesis of nitric oxide and its vasodilatatory effect during the period of incomplete spinal ischemia may account for the observed s...Continue Reading

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Citations

Aug 26, 2014·The Spine Journal : Official Journal of the North American Spine Society·Alexandra KisuckáNadežda Lukáčová
Mar 30, 1999·The Journal of Comparative Neurology·J MarsalaY Taira
May 13, 2006·Cellular and Molecular Neurobiology·Mária KolesárováJozef Marsala
Jan 28, 2005·Cellular and Molecular Neurobiology·Karolina KucharovaJozef Marsala

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