Spinal cord hypometabolism associated with infection by human T-cell lymphotropic virus type 1(HTLV-1)

PLoS Neglected Tropical Diseases
Luiz C RomanelliRodrigo Nicolato

Abstract

HTLV-1 infection is endemic in Brazil. About 1 to 2% of the Brazilian population is estimated to be infected, but most infected HTLV-1 individuals do not know about their own infection, which favors the continuity of sexual and vertical virus transmission. In addition, HTLV-1 associated central nervous system diseases and their pathophysiologic mechanisms are not fully understood. This study aimed to evaluate the correlation of spinal cord metabolism, viral and inflammatory profiles with features of neurological presentation in HTLV-1 infected individuals. This is a cross-sectional study of a cohort including 48 HTLV-1 infected individuals clinically classified as asymptomatic-AG (N = 21), symptomatic-SG (N = 11) and HAM/TSP-HG (N = 16) and a nested case-control study with HTLV-1 infected individuals-HIG (N = 48) and HTLV-1 non infected controls-CG (N = 30) that had their spinal cord analysed by Positron Emission Tomography with 18F-Fluordeoxyglucose (18F-FDG PET/CT). HTLV-1 infected individuals had 18F-FDG PET/CT results analyzed with clinical and demographic data, proviral load, cytokines and chemokines in the blood and cerebrospinal fluid (CSF). 18F-FDG PET/CT showed hypometabolism in the thoracic spinal cord in HTLV-1 infec...Continue Reading

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Citations

Sep 22, 2020·Journal of Neurovirology·Jonas Jardim de PaulaRodrigo Nicolato
Apr 2, 2020·Frontiers in Microbiology·Razieh ZargariHoushang Rafatpanah

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Methods Mentioned

BETA
ELISA
PCR
blood collection

Software Mentioned

Milliplex Analyst
SPSS
Epidata
Microsoft Exel 2008
GraphPad Prism

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