Spinal cord injury effectively ameliorated by neuroprotective effects of rosmarinic acid

Nutritional Neuroscience
Ai-Jia ShangDing-Biao Zhou

Abstract

Pathophysiology of spinal cord injury (SCI) causes primary and secondary effects leading to loss of neuronal function. The aim of the present study was to investigate the role of rosmarinic acid (RA) in protection against SCI. The experimental study was carried out in male wistar rats categorized into three groups. Group I - sham operated rats; Group II - SCI; Group III - SCI followed by RA treatment (10 mg/kg). The spinal tissues after treatment schedule were analyzed for oxidative stress status through determination of reactive oxygen species (ROS), lipid peroxidation, protein damage (carbonyl and sulfhydryl contents), and antioxidant enzyme activities. The expression of oxidative stress factors NF-κB and Nrf-2 was determined by Western blot analysis. Further pro-inflammatory cytokines (TNF-α, IL-6, MCP-1, and IL-1β) were measured by enzyme-linked immunosorbent assay (ELISA). The results show that treatment with RA significantly enhances the antioxidant status and decrease the oxidative stress in wistar rats post-SCI. RA effectively ameliorated inflammatory mechanisms by downregulation of NF-κB and pro-inflammatory cytokines post-SCI. The study demonstrates for the first time on the role of RA in protecting the spinal cord fr...Continue Reading

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Citations

May 11, 2017·Nutrients·Dominik SzwajgierKatarzyna Pustelniak
Mar 19, 2020·Frontiers in Pharmacology·Chunxu LuoShuangyong Sun
Jul 30, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Jul 18, 2020·Oxidative Medicine and Cellular Longevity·Angélica Coyoy-SalgadoCarlos E Orozco-Barrios
Jun 5, 2020·CNS & Neurological Disorders Drug Targets·Saeed SamarghandianTahereh Farkhondeh
Apr 27, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yubao LuXuegong Fan
Jul 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh AbbaszadehHaroon Khan
Mar 23, 2021·Oxidative Medicine and Cellular Longevity·Anna Lucia FedulloIlaria Peluso

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