Spinal cord injury-induced plasticity in the mouse--the crossed phrenic phenomenon

Experimental Neurology
Kenneth MinorN W Seeds

Abstract

The crossed phrenic phenomenon (CPP) describes respiratory functional plasticity that arises following spinal cord injury. Cervical spinal cord hemisection rostral to the phrenic nucleus paralyzes the ipsilateral hemidiaphragm by interrupting the descending flow of respiratory impulses from the medulla to phrenic motoneurons in the spinal cord. This loss of activity converts some synapses on phrenic motoneurons from a "functionally ineffective" state pre-hemisection to a "functionally latent" state post-hemisection. If the animal is subjected to respiratory stress by transecting the contralateral phrenic nerve, this latent respiratory pathway is activated and function is restored to the paralyzed hemidiaphragm. The mechanisms underlying this plasticity are not well-defined, particularly at the molecular level. Therefore, we explored whether it was possible to demonstrate the CPP in mice, a species amenable to a molecular genetic approach. We show the CPP qualitatively in mice using electromyographic (EMG) recordings from the diaphragm. Interestingly, our data also suggest that in the mouse latent fibers in the ventral funiculus ipsilateral to an anatomically incomplete hemisection may also play a role in the CPP. In particular,...Continue Reading

References

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Citations

May 17, 2011·Cellular and Molecular Neurobiology·Nicholas SeedsKenneth Minor
Jun 20, 2012·Journal of Neurotrauma·Krishna Kumar VeeravalliJasti S Rao
Sep 8, 2010·Experimental Neurology·K QiuD D Fuller
Aug 25, 2009·Respiratory Physiology & Neurobiology·Michael A LanePaul J Reier
Aug 5, 2009·Respiratory Physiology & Neurobiology·Nicholas W SeedsKenneth Minor
Aug 18, 2009·Respiratory Physiology & Neurobiology·Stéphane Vinit, Anne Kastner
Jun 23, 2009·Respiratory Physiology & Neurobiology·Harry G Goshgarian
Jan 20, 2009·Respiratory Physiology & Neurobiology·D D FullerP J Reier
Sep 9, 2008·Trends in Neurosciences·Michael A LanePaul J Reier
Nov 29, 2007·Molecular and Cellular Neurosciences·Kenneth H Minor, Nicholas W Seeds
Jul 3, 2007·Experimental Neurology·M Beth ZimmerHarry G Goshgarian
Feb 19, 2008·The European Journal of Neuroscience·Stéphane VinitAnne Kastner
Aug 26, 2014·Respiratory Physiology & Neurobiology·Philippa M WarrenWarren J Alilain
Apr 16, 2013·Experimental Neurology·Carlos B MantillaGary C Sieck
Oct 4, 2011·Experimental Neurology·Michael A LanePaul J Reier
Jul 6, 2007·The European Journal of Neuroscience·Stéphane VinitAnne Kastner
Aug 25, 2020·The Journal of Physiology·Donald C Bolser
Aug 2, 2017·Neural Regeneration Research·Michael George Zaki Ghali
Nov 5, 2020·Respiratory Physiology & Neurobiology·Pauline Michel-FlutotStéphane Vinit

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