Spinal cord injury induces changes in electrophysiological properties and ion channel expression of reticulospinal neurons in larval lamprey

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
A D McClellanDavid J Schulz

Abstract

In larval lamprey, hemitransections were performed on the right side of the rostral spinal cord to axotomize ipsilateral reticulospinal (RS) neurons. First, at short recovery times (2-3 weeks), uninjured RS neurons contralateral to hemitransections fired a smooth train of action potentials in response to sustained depolarization, whereas axotomized neurons fired a single short burst or short repetitive bursts. For uninjured RS neurons, the afterpotentials of action potentials had three components: fast afterhyperpolarization (fAHP), afterdepolarizing potential (ADP), and slow AHP (sAHP) that was attributable to calcium influx via high-voltage-activated (HVA) (N- and P/Q-type) calcium channels and calcium-activated potassium channels (SKKCa). For axotomized RS neurons, the fAHP was significantly larger than for uninjured neurons, and the ADP and sAHP were absent or significantly reduced. Second, at relatively long recovery times (12-16 weeks), axotomized RS neurons displayed firing patterns and afterpotentials that were similar to those of uninjured neurons. Third, mRNA levels of lamprey HVA calcium and SKKCa channels in axotomized RS neurons were significantly reduced at short recovery times and restored at long recovery times....Continue Reading

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Citations

Apr 22, 2008·Nature Reviews. Neuroscience·Heinz Beck, Yoel Yaari
Apr 2, 2013·Tissue Engineering. Part B, Reviews·Kanika Vats, Danielle S W Benoit
Apr 16, 2013·Biochimica Et Biophysica Acta·Yu-Jung ChangLinyi Chen
Mar 31, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Pazit Polak, Orit Shefi
Aug 1, 2011·Biomolecular Concepts·Rajiv Wijesinghe, Aaron J Camp
Dec 29, 2013·Journal of Neurophysiology·Nicholas D Vesprini, Gaynor E Spencer
Oct 25, 2014·Journal of Neurophysiology·Nicholas D VespriniGaynor E Spencer
Jul 23, 2020·Journal of Neurophysiology·Jeffrey A Ruffolo, Andrew D McClellan
May 5, 2017·Journal of Neurophysiology·Jessica A BenesAndrew D McClellan
Dec 4, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Ji Sun ParkKeun-Hong Park

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