Spinal cord injury induces differential expression of the profibrotic semaphorin 7A in the developing and mature glial scar

Glia
Marcel A KoppHarald Prüss

Abstract

Semaphorin 7A (Sema7A) is involved in the formation of the central nervous system during development by operating axon guidance and neuronal migration. We investigated the expression of the TGFβ-inducible Sema7A following spinal cord injury (SCI). After SCI, Sema7A(+) cells accumulated specifically in lesion areas resulting in significantly enhanced Sema7A expression at the injury site (P < 0.0001). During the first days lesional Sema7A expression was confined to neurons, ballooned neurite fibers/retraction bulbs, and endothelial cells. At day 7, we observed Sema7A expression by components of the glial scar, such as reactive astrocytes and pronounced extracellular Sema7A deposition. In the direct perilesional rim, Sema7A(+) astrocytes coexpressed the activation-associated intermediate filament vimentin. In the injured spinal cord, numbers of Sema7A(+) cells reached maximum levels at day 14. The restricted accumulation of Sema7A(+) reactive astrocytes and Sema7A deposition in fibronectin(+) extracellular matrix territories suggests a participation of the fibrostimulatory Sema7A in the developing and maturating scar following SCI. In addition, Sema7A appears to be marker a for astrocyte activation.

References

May 1, 1994·Journal of Neuropathology and Experimental Neurology·M D Norenberg
Sep 1, 1993·Trends in Pharmacological Sciences·A Logan, M Berry
Apr 1, 1996·Physiological Reviews·M E Schwab, D Bartholdi
Sep 2, 1998·Cell and Tissue Research·C C Stichel, H W Müller
Jan 8, 1999·Biochimica Et Biophysica Acta·Y Sato, H Takahashi
Feb 23, 1999·Neuron·H H Yu, A L Kolodkin
Sep 14, 1999·Brain Research Bulletin·J W Fawcett, R A Asher
Jan 29, 2000·The European Journal of Neuroscience·M HertelS Werner
May 16, 2002·Experimental Neurology·F De WinterJ Verhaagen
Aug 24, 2002·Scandinavian Journal of Immunology·S HolmesC Lewis
Feb 11, 2003·Advances in Experimental Medicine and Biology·Ann Logan, Martin Berry
Jul 25, 2003·Nature·R Jeroen PasterkampAlex L Kolodkin
Jan 22, 2004·Nature Reviews. Neuroscience·Jerry Silver, Jared H Miller
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jill R FaulknerMichael V Sofroniew
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew Leask, David J Abraham
Sep 29, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shomron Ben-Horin, Ilan Bank
Apr 23, 2005·The European Journal of Neuroscience·Jan M SchwabHermann J Schluesener
Apr 30, 2005·Biology of the Cell·Guillaume DelormeIrma Machuca-Gayet
Apr 25, 2006·Journal of Neurotrauma·Simone P NiclouJoost Verhaagen
May 23, 2006·Immunity·Agnieszka K CzopikRuslan Medzhitov
Oct 31, 2006·Brain : a Journal of Neurology·Jennifer C FlemingLynne C Weaver
Mar 27, 2007·Advances in Immunology·Hitoshi KikutaniAtsushi Kumanogoh
May 9, 2007·The Journal of Experimental Medicine·Hye-Ryun KangJack A Elias
Jun 23, 2009·Current Opinion in Neurobiology·R Jeroen Pasterkamp, Roman J Giger

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Citations

Oct 2, 2013·Immunobiology·Bénédicte Chazaud
Oct 11, 2014·Gene·Aisling M O'MalleyDenis S Barry
Dec 22, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ana Gutiérrez-FrancoCarmen Espejo
Feb 20, 2013·Trends in Molecular Medicine·Herena EixarchCarmen Espejo
Jan 22, 2013·Seminars in Cell & Developmental Biology·Bart C JongbloetsR Jeroen Pasterkamp
Nov 14, 2013·Immunologic Research·Ramon Garcia-AreasVijaya Iragavarapu-Charyulu
Apr 2, 2014·Journal of Neuroscience Research·Maosheng Xia, Yue Zhu
Aug 15, 2014·Journal of Molecular Neuroscience : MN·Maosheng Xia, Yue Zhu
Oct 8, 2016·Molecular Neurobiology·Ana Gutiérrez-FrancoCarmen Espejo
Oct 4, 2015·Multiple Sclerosis : Clinical and Laboratory Research·C CostaC Espejo
Oct 4, 2015·Multiple Sclerosis : Clinical and Laboratory Research·David KremerPatrick Küry
Apr 25, 2019·European Journal of Immunology·Joshua GhofraniStephanie Jost
Mar 27, 2020·Frontiers in Immunology·Vijaya Iragavarapu-CharyuluAlexandra Urdaneta
Mar 24, 2021·International Immunopharmacology·Ramin LotfiFatemeh Zamani
May 22, 2021·Neuroscience Research·Tetsuya Takano, Scott H Soderling
Jul 17, 2021·Neural Regeneration Research·Bor Luen Tang
Aug 8, 2021·International Journal of Molecular Sciences·Miguel E Domínguez-Romero, Paula G Slater

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