Spinal cord is required for proper regeneration of the tail in Xenopus tadpoles

Development, Growth & Differentiation
Yuka TaniguchiMakoto Mochii

Abstract

Tail regeneration in urodeles is dependent on the spinal cord (SC), but it is believed that anuran larvae regenerate normal tails without the SC. To evaluate the precise role of the SC in anuran tail regeneration, we developed a simple operation method to ablate the SC completely and minimize the damage to the tadpole using Xenopus laevis. The SC-ablated tadpole regenerated a twisted and smaller tail. These morphological abnormalities were attributed to defects in the notochord (NC), as the regenerated NC in the SC-ablated tail was short, slim and twisted. The SC ablation never affected the early steps of the regeneration, including closure of the amputated surface with epidermis and accumulation of the NC precursor cells. The proliferation rate of the NC precursor cells, however, was reduced, and NC cell maturation was retarded in the SC-ablated tail. These results show that the SC has an essential role in the normal tail regeneration of Xenopus larvae, especially in the proliferation and differentiation of the NC cells. Gene expression analysis and implantation of a bead soaked with growth factor showed that fibroblast growth factor-2 and -10 were involved in the signaling molecules, which were expressed in the SC and stimula...Continue Reading

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Citations

Feb 16, 2010·Development, Growth & Differentiation·Keisuke MorichikaMakoto Mochii
Nov 17, 2011·BMC Developmental Biology·Nick R LoveEnrique Amaya
Jun 25, 2009·BMC Developmental Biology·Christoph WaldnerGerhart U Ryffel
Jun 20, 2014·BMC Developmental Biology·Yuka TaniguchiMakoto Mochii
Nov 10, 2010·Brain Research Reviews·Ruxandra F Sîrbulescu, Günther K H Zupanc
Mar 13, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Caroline W BeckBea Christen
Aug 31, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Gufa LinJonathan M W Slack
May 23, 2014·Biochemical Society Transactions·Yaoyao ChenEnrique Amaya
Sep 20, 2012·Trends in Neurosciences·Anoop Kumar, Jeremy P Brockes
Sep 8, 2009·Developmental Biology·Brian ReidMin Zhao
Dec 4, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Akira IimuraMorioh Kusakabe
Feb 26, 2019·Frontiers in Physiology·Anneke D Kakebeen, Andrea E Wills
Mar 21, 2020·Development·Lauren S PhippsEnrique Amaya
Jan 23, 2021·Journal of Cell Communication and Signaling·René Fernando Abarca-BuisEdgar Krötzsch
Apr 28, 2021·Explore : the Journal of Science and Healing·K E Thorp
Feb 7, 2019·Developmental Neurobiology·Polina D FreitasJames R Monaghan
Mar 31, 2021·Cold Spring Harbor Protocols·Paula G SlaterJuan Larraín
Aug 14, 2021·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Sakiya YamamotoAkira Satoh
Nov 17, 2021·Medicinal Research Reviews·Rita C Assunção SilvaAntónio J Salgado

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