Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy

Neuromodulation : Journal of the International Neuromodulation Society
Krishnan ChakravarthyYun Guan

Abstract

Traditional spinal cord stimulation (SCS) requires that paresthesia overlaps chronic painful areas. However, the new paradigm high-frequency SCS (HF-SCS) does not rely on paresthesia. A review of preclinical and clinical studies regarding the use of paresthesia-free HF-SCS for various chronic pain states. We reviewed available literatures on HF-SCS, including Nevro's paresthesia-free ultra high-frequency 10 kHz therapy (HF10-SCS). Data sources included relevant literature identified through searches of PubMed, MEDLINE/OVID, and SCOPUS, and manual searches of the bibliographies of known primary and review articles. The primary goal is to describe the present developing conceptions of preclinical mechanisms of HF-SCS and to review clinical efficacy on paresthesia-free HF10-SCS for various chronic pain states. HF10-SCS offers a novel pain reduction tool without paresthesia for failed back surgery syndrome and chronic axial back pain. Preclinical findings indicate that potential mechanisms of action for paresthesia-free HF-SCS differ from those of traditional SCS. To fully understand and utilize paresthesia-free HF-SCS, mechanistic study and translational research will be very important, with increasing collaboration between basic ...Continue Reading

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Citations

Mar 12, 2018·Pain Practice : the Official Journal of World Institute of Pain·Andrei D SdrullaSrinivasa N Raja
Dec 18, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Zhiyong ChenYun Guan
Jun 5, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Fei YangYun Guan
Jun 22, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Adantchede L ZannouMarom Bikson
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Dec 7, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Martine BordeleauMichel Prud'Homme
Aug 10, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Wanru DuanYun Guan
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Jun 4, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Krishnan ChakravarthyRobert Levy
Aug 9, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Adnan Al-KaisyThomas Yearwood
Aug 23, 2019·Bioelectronic Medicine·Jacob CaylorImanuel Lerman
Aug 6, 2020·Healthcare Technology Letters·Casey J Steadman, Warren M Grill

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