Spinal cord stimulation protects against atrial fibrillation induced by tachypacing.

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Scott A BernsteinGregory E Morley

Abstract

Spinal cord stimulation (SCS) has been shown to modulate atrial electrophysiology and confer protection against ischemia and ventricular arrhythmias in animal models. To determine whether SCS reduces the susceptibility to atrial fibrillation (AF) induced by tachypacing (TP). In 21 canines, upper thoracic SCS systems and custom cardiac pacing systems were implanted. Right atrial and left atrial effective refractory periods were measured at baseline and after 15 minutes of SCS. Following recovery in a subset of canines, pacemakers were turned on to induce AF by alternately delivering TP and searching for AF. Canines were randomized to no SCS therapy (CTL) or intermittent SCS therapy on the initiation of TP (EARLY) or after 8 weeks of TP (LATE). AF burden (percent AF relative to total sense time) and AF inducibility (percentage of TP periods resulting in AF) were monitored weekly. After 15 weeks, echocardiography and histology were performed. Effective refractory periods increased by 21 ± 14 ms (P = .001) in the left atrium and 29 ± 12 ms (P = .002) in the right atrium after acute SCS. AF burden was reduced for 11 weeks in EARLY compared with CTL (P <.05) animals. AF inducibility remained lower by week 15 in EARLY compared with CT...Continue Reading

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Citations

Feb 27, 2014·Journal of Cardiovascular Translational Research·John C Lopshire, Douglas P Zipes
Oct 11, 2014·Autonomic Neuroscience : Basic & Clinical·Jeffrey L ArdellJ Andrew Armour
Jan 19, 2016·Progress in Biophysics and Molecular Biology·Crystal M RipplingerDominik Linz
Oct 7, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yuemei HouSunny S Po
Oct 6, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Marmar Vaseghi, Kalyanam Shivkumar
May 23, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yoram Etzion
Aug 19, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Songyun WangHong Jiang
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Apr 6, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Qingyan ZhaoCongxin Huang
Feb 22, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael ManogueMichael Lloyd
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Jun 6, 2015·Circulation Research·Keiichi FukudaKalyanam Shivkumar
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May 15, 2021·Cardiovascular Research·Peter HannaKalyanam Shivkumar
May 30, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Neal A Chatterjee, Jagmeet P Singh

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