Spinal cord stimulation protects against ventricular arrhythmias by suppressing left stellate ganglion neural activity in an acute myocardial infarction canine model

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Songyun WangHong Jiang

Abstract

Previous studies have shown that spinal cord stimulation (SCS) may reduce ventricular arrhythmias (VAs) induced by acute myocardial infarction (AMI). Furthermore, activation of left stellate ganglion (LSG) appears to facilitate VAs after AMI. The purpose of this study was to investigate whether pretreatment with SCS could protect against VAs by reducing LSG neural activity in an AMI canine model. Thirty dogs were anesthetized and randomly divided into SCS group (with SCS, n = 15) and sham group (sham operation without SCS, n = 15). SCS was performed for 1 hour before AMI. Heart rate variability (HRV), ventricular effective refractory period (ERP), serum norepinephrine level, LSG function measured by blood pressure increases in response to LSG stimulation, and LSG neural activity were measured for 1 minute at baseline and 1 hour after SCS. AMI was induced by left anterior descending coronary artery ligation, and then HRV, LSG neural activity, and VAs were measured. Compared to baseline, SCS for 1 hour significantly prolonged ventricular ERP, increased HRV, and attenuated LSG function and LSG activity in the SCS group, whereas no significant change was shown in the sham group. AMI resulted in a significant decrease in HRV and inc...Continue Reading

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Citations

Jan 19, 2016·Progress in Biophysics and Molecular Biology·Crystal M RipplingerDominik Linz
Aug 19, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Songyun WangHong Jiang
Nov 27, 2015·International Journal of Cardiology·Ling ZhangBaopeng Tang
Jul 15, 2015·International Journal of Cardiology·Mingxian ChenShenghua Zhou
May 20, 2015·International Journal of Cardiology·Songyun WangHong Jiang
Jan 26, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Wenbo HeHong Jiang
Sep 15, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Louis A SaddicAman Mahajan
Dec 12, 2019·Pacing and Clinical Electrophysiology : PACE·Perry Wu, Marmar Vaseghi
Nov 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Siamak SalavatianJeffrey L Ardell
Jun 15, 2019·Nature Reviews. Cardiology·Neil HerringDavid J Paterson
May 5, 2017·Journal of Cardiovascular Electrophysiology·Ricardo Cardona-GuaracheJayanthi N Koneru
Jun 4, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Kimberly Howard-QuijanoAman Mahajan
Mar 20, 2019·Current Cardiology Reports·Veronica DusiOlujimi A Ajijola
Apr 9, 2018·Current Treatment Options in Cardiovascular Medicine·Lingjin MengOlujimi Ajijola
Mar 28, 2019·Frontiers in Physiology·Yanqiu LaiHong Jiang
Jan 20, 2021·ESC Heart Failure·Ewa Pius-Sadowska, Bogusław Machaliński
Aug 31, 2019·JACC. Basic to Translational Science·Nathan H WaldronJonathan P Piccini
Jan 19, 2021·Clinical and Experimental Pharmacology & Physiology·Lijun ChengGuangping Li
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May 30, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Neal A Chatterjee, Jagmeet P Singh
Jul 31, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Joshua Manuel MartensAlaa Abd-Elsayed
Oct 1, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Valerie Y H van WeperenOlujimi A Ajijola

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