Spinal corollary discharge modulates motion sensing during vertebrate locomotion

Nature Communications
Boris P ChagnaudHans Straka

Abstract

During active movements, neural replicas of the underlying motor commands may assist in adapting motion-detecting sensory systems to an animal's own behaviour. The transmission of such motor efference copies to the mechanosensory periphery offers a potential predictive substrate for diminishing sensory responsiveness to self-motion during vertebrate locomotion. Here, using semi-isolated in vitro preparations of larval Xenopus, we demonstrate that shared efferent neural pathways to hair cells of vestibular endorgans and lateral line neuromasts express cyclic impulse bursts during swimming that are directly driven by spinal locomotor circuitry. Despite common efferent innervation and discharge patterns, afferent signal encoding at the two mechanosensory peripheries is influenced differentially by efference copy signals, reflecting the different organization of body/water motion-detecting processes in the vestibular and lateral line systems. The resultant overall gain reduction in sensory signal encoding in both cases, which likely prevents overstimulation, constitutes an adjustment to increased stimulus magnitudes during locomotion.

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Citations

Aug 22, 2017·Frontiers in Physiology·Miranda A MathewsAndrew J Murray
Nov 5, 2016·The Journal of Experimental Biology·Sara Hänzi, Hans Straka
Apr 23, 2016·The Journal of Experimental Biology·Géraldine von UckermannJohn Simmers
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Mar 9, 2017·Journal of Neurology·Hans Straka, Boris P Chagnaud
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Oct 24, 2019·Journal of Neurophysiology·Elias T LunsfordJames C Liao
Jan 8, 2020·Current Biology : CB·Dena S Goldblatt, David Schoppik
Jul 13, 2021·Frontiers in Neuroscience·Kathleen E Cullen, Rui-Han Wei
Oct 12, 2021·PLoS Biology·Dimitri A SkandalisJames C Liao
Oct 28, 2021·Journal of Neurophysiology·Valentina SaccomannoWen-Chang Li
Oct 31, 2021·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Jackson RossboroughLarry F Hoffman
Nov 26, 2021·Current Biology : CB·Iris OdstrcilFlorian Engert

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Methods Mentioned

BETA
light microscopy

Software Mentioned

Igor pro
Spike
MBF
ImageJ

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