Spinal effects of the fesoterodine metabolite 5-hydroxymethyl tolterodine and/or doxazosin in rats with or without partial urethral obstruction

The Journal of Urology
Claudius FüllhaseKarl-Erik Andersson

Abstract

The combination of muscarinic receptor and alpha(1)-adrenoceptor antagonists is increasingly used for benign prostatic hyperplasia related lower urinary tract symptoms. In addition to the well established peripheral site of action, little is known about the central effects of muscarinic receptor antagonists and muscarinic receptor/alpha(1)-adrenoceptor antagonist combinations on bladder function, partly due to poor brain penetration after systemic administration. We assessed the effects of intrathecal 5-hydroxymethyl tolterodine, an active metabolite of fesoterodine, in obstructed and nonobstructed rats, and of combined intrathecal 5-hydroxymethyl tolterodine/doxazosin in a rat model of partial urethral obstruction. We used 80 male Sprague-Dawley rats to test various doses of intrathecal 5-hydroxymethyl tolterodine and/or intrathecal doxazosin on urodynamic parameters. Urodynamic evaluation without anesthesia was done 3 days after bladder and intrathecal catheterization. Two weeks before urodynamics 40 rats underwent partial urethral obstruction. Intrathecal 5-hydroxymethyl tolterodine had no urodynamic effects in nonobstructed rats. Compared to controls obstructed rats had increased bladder pressure and weight, and voiding fre...Continue Reading

References

Apr 1, 1991·The Journal of Urology·J L MostwinE L Brooks
Aug 13, 2003·The Journal of Urology·Annette SchröderKarl-Erik Andersson
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy
Nov 16, 2006·JAMA : the Journal of the American Medical Association·Steven A KaplanZhonghong Guan
Jul 7, 2007·Nature Clinical Practice. Urology·Karl-Erik Andersson, Christian Gratzke
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Oct 10, 2007·BJU International·Paul Abrams, Karl-Erik Andersson
Apr 22, 2008·European Urology·Christopher R ChappleClaus G Roehrborn

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Citations

Apr 20, 2014·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Martin HennenbergChristian Gratzke
May 29, 2013·European Urology·Roberto SolerFrancisco Cruz
Sep 11, 2012·European Urology·Christian Gratzke, Karl-Erik Andersson
Jun 11, 2011·Neurourology and Urodynamics·Karl-Erik AnderssonClaudius Füllhase
Apr 14, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Biao ChenXiao-Yan Huang

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