Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats

Experimental Neurology
Célia CruzF Cruz

Abstract

The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses. In the mammalian nervous system, the ERK pathway has been found to mediate plasticity events. Particularly, in the spinal cord, ERK play an important role in allodynia and hyperalgesia. Recently, it was demonstrated that ERK activation is upregulated in the spinal cord of rats with chronic bladder inflammation and contributes to bladder overactivity. Thus, in this study we sought to assess the involvement of ERK in micturition reflexes associated to spinal cord injury (SCI) in the rat. Bladder function in chronic SCI rats was altered compared to spinal intact rats. PhosphoERK levels were upregulated in the L6 spinal cord segment, particularly after saline infusion for 2 h. The increase in spinal ERK phosphorylation was specifically restricted to L6 spinal segment. No variation in the levels of total ERK protein was observed. Intrathecal administration of PD98059, a specific inhibitor of ERK phosphorylation, reduced the frequency and amplitude of bladder contractions in SCI animals but not in spinal inta...Continue Reading

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Citations

May 2, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Simone D GueriosDale E Bjorling
Apr 3, 2014·Human Molecular Genetics·Neil A RobertsEmma N Hilton
Jun 19, 2013·Neurourology and Urodynamics·Célia Duarte Cruz
Sep 1, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Neil A RobertsAdrian S Woolf
Nov 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Li-Ya Qiao, Melisa A Gulick
Jul 19, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Nasrin AbolhasanpourHashim Hashim
Feb 9, 2011·Expert Opinion on Pharmacotherapy·Anastasios Athanasopoulos, Francisco Cruz

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