Spinal expression of mRNA for immediate early genes in a model of chronic pain

Acta Physiologica Scandinavica
G E DelanderB B Fredholm

Abstract

We have used a partial nerve ligation model of chronic pain to investigate if there are changes in the expression of mRNA for several immediate early genes (IEG) that correlate in time with the initial adaptive behavioural changes and with development of allodynia in this model. The animals were inspected for typical changes in posture, and mechanical allodynia was evaluated using von Frey filaments. Expression of three of the immediate early genes examined, c-fos, NGFI-A and jun B, was transiently increased in the ipsilateral dorsal horn of the spinal cord following the partial ligation of the sciatic nerve. The time course and extent of these changes were similar to those reported for acute noxious stimuli. c-jun mRNA expression was significantly enhanced, after a delay of more than 12 h, and then remained elevated over the entire studied period of 4 weeks. These changes occurred only in the ventral horn, particularly in lamina IX. Except for c-jun mRNA, all changes were transient despite behavioural evidence for continuing allodynia. These results from the partial nerve ligation model, when compared with results obtained using other models of acute or chronic nerve injury, suggest that the immediate early genes we have exami...Continue Reading

Citations

Feb 5, 2004·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Partap S Khalsa
Jan 29, 2002·Anesthesia and Analgesia·Caroline E HeughanJana Sawynok
Mar 23, 2011·Journal of Neuroscience Research·Wenguo FanHongwen He
Jul 23, 2013·European Journal of Pain : EJP·W M OlangoD P Finn
Jan 5, 2005·The Journal of Pain : Official Journal of the American Pain Society·Shanelle W KoMin Zhuo
Mar 21, 2003·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Atsuhiro Sakamoto
Jan 9, 2003·Best Practice & Research. Clinical Anaesthesiology·Steen Petersen-Felix, Lars Arendt-Nielsen
Jun 19, 2013·Surgical Neurology International·Ahmed J AwadPeter Konrad

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