Spinal hemorrhages are associated with early neonatal motor function loss in human spina bifida aperta

Early Human Development
Deborah A SivalWilfred F A den Dunnen

Abstract

In spina bifida aperta (SBA), leg movements caudal to the meningomyelocele are present in utero, but they disappear shortly after birth. It is unclear whether leg movements disappear by impact of the neuro-developmental malformation or by superimposed traumatic damage. If superimposed traumatic damage is involved, targeted fetal intervention could improve motor outcome. To characterize neuromuscular pathology in association with perinatal motor function loss in SBA. In fetal SBA (n=8; 16-40 weeks GA), the median time interval between ultrasound registrations of fetal motor behavior and post-mortem histology was 1 week. Histology was assessed cranial, at and caudal to the meningomyelocele and compared with findings in fetal controls (n=4). Despite fetal movements caudal to the meningomyelocele (5/6), histology indicated muscle fiber alterations (6/6) that concurred with neuro-developmental and traumatic spinal defects [Neuro-developmental defects: spinal ependymal denudation (3/8), reduced amount of (caspase3-negative) lower motor neurons (LMNs; 8/8), aberrant spinal vascularization (8/8). Traumatic defects: gliosis (7/8), acute/fresh spinal hemorrhages near LMNs (8/8)]. In all delivered SBA patients, recent spinal hemorrhages w...Continue Reading

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Citations

Mar 4, 2008·Cerebrospinal Fluid Research·Olga A de WitDeborah A Sival
Nov 10, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R J VerbeekD A Sival
Nov 12, 2013·Ultrasound in Medicine & Biology·Renate J VerbeekDeborah A Sival
Jun 16, 2012·Ultrasound in Medicine & Biology·Rick BrandsmaDeborah A Sival
May 19, 2009·Early Human Development·R J VerbeekD A Sival
Jul 13, 2011·Developmental Medicine and Child Neurology·Enrico DanzerN Scott Adzick
Dec 1, 2011·Developmental Medicine and Child Neurology·Renate J VerbeekDeborah A Sival
Jan 29, 2011·Brain Pathology·Deborah A SivalEsteban M Rodríguez
Aug 19, 2011·Fetal Diagnosis and Therapy·Enrico Danzer, N Scott Adzick
Dec 17, 2019·Developmental Medicine and Child Neurology·Enrico DanzerJan Deprest
Apr 2, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Hérbene José Figuinha MilaniAntonio Fernandes Moron
Jul 31, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R CorroenneM Sanz Cortes
Apr 14, 2020·American Journal of Obstetrics and Gynecology·Selima Ben MiledJulien Stirnemann

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