Spinal interneuronal mechanisms underlying pudendal and tibial neuromodulation of bladder function in cats

Experimental Neurology
Todd YeciesChangfeng Tai

Abstract

This study examined the mechanisms underlying pudendal and tibial neuromodulation of bladder function at the single neuron level in the spinal cord. A microelectrode was inserted into the S2 spinal cord of anesthetized cats to record single neuron activity induced by bladder distention over a range of constant intravesical pressures (10-40 cmH2O). Pudendal nerve stimulation (PNS) or tibial nerve stimulation (TNS) was applied at 5 Hz frequency and 0.2 ms pulse width and at multiples of the threshold (T) intensities for inducing anal or toe twitches. A total of 14 spinal neurons from 11 cats were investigated. Both PNS and TNS at 2 T intensity significantly (p < .05) reduced by 40-50% the frequency of firing induced by bladder distention at 20-40 cmH2O in the same spinal neurons. This reduction was not changed by blocking opioid receptors with naloxone (1 mg/kg, i.v.). Activation of pudendal afferents by repeatedly stroking (3-5 times per second) the genital skin using a cotton swab also inhibited the neuron activity induced by bladder distention. Prolonged (30 min) TNS at 4 T intensity produced a short lasting (10-18 min) post-stimulation inhibition that reduced by 40-50% bladder-related neuron activity at different bladder pres...Continue Reading

Citations

Jan 9, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shun LiChangfeng Tai
Mar 3, 2020·Frontiers in Neuroscience·Katherine ShapiroChangfeng Tai
Nov 5, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anand MohapatraChangfeng Tai
Jun 24, 2020·Peptides·Richard J Bodnar
May 12, 2021·Current Pain and Headache Reports·Natalie H StrandJillian Maloney

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