Spinal involvement in juvenile idiopathic arthritis: what do we miss without imaging?

Rheumatology International
Selcan DemirSeza Özen

Abstract

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood. Enthesitis-related arthritis (ERA) has been one of the most controversial subtypes of JIA with a higher risk of axial involvement.  Our aim was to assess the frequency and spectrum of MRI findings of spine involvement in patients with JIA and determine if the axial involvement is always clinically symptomatic in patients with positive MRI findings. In this retrospective cross-sectional observational study we included known or suspected JIA patients who underwent spinal MRI examination between 2015 and 2017 and followed up in the Pediatric Rheumatology outpatient clinic. The demographic and clinical data were reviewed from the medical charts and electronic records. All patients were grouped as clinically symptomatic and asymptomatic for spinal involvement and MRI findings were re-evaluated for presence of inflammatory and erosive lesions. Of the 72 JIA patients, 57 (79.2%) were diagnosed with ERA, and 15 (20.8%) with non-ERA subtypes of JIA. Overall, 49 (68%) patients with JIA had positive spinal MRI findings (inflammatory and/or erosive lesions). Twenty-seven (47%) ERA patients were clinically symptomatic for spine involvement and amo...Continue Reading

References

May 25, 2002·Joint, Bone, Spine : Revue Du Rhumatisme·Agnès Bouchaud-Chabot, Frédéric Lioté
Oct 2, 2002·Arthritis and Rheumatism·Kirsten MindenAngela Zink
Oct 17, 2002·Rheumatic Diseases Clinics of North America·Rubén Burgos-Vargas
Mar 21, 2006·Best Practice & Research. Clinical Rheumatology·Karen Davies, Annabel Copeman
Apr 11, 2012·Nature Reviews. Rheumatology·Shirley M L Tse, Ronald M Laxer
Mar 22, 2013·Therapeutic Advances in Musculoskeletal Disease·Denis Poddubnyy
Mar 7, 2014·Pediatric Rheumatology Online Journal·Toni HospachThekla von Kalle
Apr 4, 2015·Annals of the Rheumatic Diseases·P MandlUNKNOWN European League Against Rheumatism (EULAR)
Jan 30, 2016·Current Treatment Options in Rheumatology·Sabrina Gmuca, Pamela F Weiss
Oct 18, 2016·Rheumatology and Therapy·Gabriella GiancaneAngelo Ravelli
Aug 6, 2017·Autoimmunity Reviews·Rolando CimazAlberto Martini
Oct 28, 2017·Journal of Ultrasonography·Iwona Sudoł-SzopińskaSlavcho Ivanoski
Oct 11, 2020·Best Practice & Research. Clinical Rheumatology·Pamela F Weiss, Nancy A Chauvin

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