Spinal-like regulator facilitates control of a two-degree-of-freedom wrist.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Giby RaphaelGerald E Loeb

Abstract

The performance of motor tasks requires the coordinated control and continuous adjustment of myriad individual muscles. The basic commands for the successful performance of a sensorimotor task originate in "higher" centers such as the motor cortex, but the actual muscle activation and resulting torques and motion are considerably shaped by the integrative function of the spinal interneurons. The relative contributions of brain and spinal cord are less clear for reaching movements than for automatic tasks such as locomotion. We have modeled a two-axis, four-muscle wrist joint with realistic musculoskeletal mechanics and proprioceptors and a network of regulatory circuitry based on the classical types of spinal interneurons (propriospinal, monosynaptic Ia-excitatory, reciprocal Ia-inhibitory, Renshaw inhibitory, and Ib-inhibitory pathways) and their supraspinal control (via biasing activity, presynaptic inhibition, and fusimotor gain). The modeled system has a very large number of control inputs, not unlike the real spinal cord that the brain must learn to control to produce desired behaviors. It was surprisingly easy to program this model to emulate actual performance in four very different but well described behaviors: (1) stab...Continue Reading

Citations

May 18, 2012·Journal of Neurophysiology·Christopher J HassonDagmar Sternad
Jul 25, 2014·PLoS Computational Biology·Hugo Gravato MarquesFumiya Iida
Nov 8, 2012·Biological cybernetics·Agneta GustusPatrick van der Smagt
Aug 17, 2012·Biological cybernetics·Gerald E Loeb
Nov 21, 2014·Biomedical Engineering Online·Filip Stefanovic, Henrietta L Galiana
Feb 13, 2016·Frontiers in Computational Neuroscience·M Hongchul Sohn, Lena H Ting
Jul 10, 2013·The Journal of Physiology·Paul DeanHenrik Jörntell
Dec 6, 2011·Neural Networks : the Official Journal of the International Neural Network Society·Mehrdad YazdaniRobert Hecht-Nielsen
Oct 27, 2015·Frontiers in Computational Neuroscience·Reza Sharif RazavianJohn McPhee
Sep 3, 2013·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Filip Stefanovic, Henrietta Galiana
Jun 10, 2015·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Filip Stefanovic, Henrietta L Galiana
May 16, 2015·Current Opinion in Neurobiology·Robert M BrownstoneNicolas Stifani
Jun 20, 2015·Frontiers in Computational Neuroscience·Gerald E Loeb, George A Tsianos
Nov 18, 2014·Frontiers in Neuroscience·Gerald E Loeb, Jeremy A Fishel
May 2, 2014·Frontiers in Neurology·Emily L LawrenceFrancisco J Valero-Cuevas
Nov 27, 2014·Frontiers in Computational Neuroscience·Thomas Buhrmann, Ezequiel A Di Paolo
Sep 30, 2016·Journal of Computational Neuroscience·Bernard Grandjean, Marc A Maier
Oct 10, 2014·PLoS Computational Biology·Frédéric Crevecoeur, Stephen H Scott
Mar 31, 2017·Journal of Neurophysiology·Alejandro Melendez-CalderonJames L Patton
Jan 18, 2017·Journal of Neural Engineering·Kian JalaleddiniFrancisco J Valero-Cuevas
Sep 29, 2012·Journal of Neurophysiology·Aymar de RugyTimothy J Carroll
Aug 2, 2014·Journal of Neural Engineering·George A TsianosGerald E Loeb
Aug 23, 2018·Journal of Neurophysiology·Frederic Crevecoeur, Isaac Kurtzer
Oct 9, 2015·Journal of Neurophysiology·Jeffrey WeilerJ Andrew Pruszynski
Aug 24, 2017·Journal of Neural Engineering·M CouraudA de Rugy
Oct 12, 2018·Journal of the Royal Society, Interface·Shota Hagio, Motoki Kouzaki
May 2, 2019·Frontiers in Computational Neuroscience·Reza Sharif RazavianJohn McPhee
Oct 13, 2017·The Journal of Physiology·Kian JalaleddiniFrancisco J Valero-Cuevas
Sep 27, 2018·Frontiers in Computational Neuroscience·Brian A CohnFrancisco J Valero-Cuevas
Mar 23, 2021·Frontiers in Neuroscience·Beck StrohmerLeon Bonde Larsen
Feb 20, 2021·Journal of Human Kinetics·Gerald E Loeb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Neuroscience
Emanuel Todorov, Michael I Jordan
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Aymar de RugyTimothy J Carroll
© 2021 Meta ULC. All rights reserved