Spinal neuronal activation during locomotor-like activity enabled by epidural stimulation and 5-hydroxytryptamine agonists in spinal rats

Journal of Neuroscience Research
Paul DuruR R Roy

Abstract

The neural networks that generate stepping in complete spinal adult rats remain poorly defined. To address this problem, we used c-fos (an activity-dependent marker) to identify active interneurons and motoneurons in the lumbar spinal cord of adult spinal rats during a 30-min bout of bipedal stepping. Spinal rats were either step trained (30 min/day, 3 days/week, for 7.5 weeks) or not step trained. Stepping was enabled by epidural stimulation and the administration of the serotonergic agonists quipazine and 8-OHDPAT. A third group of spinal rats served as untreated (no stimulation, drugs, or stepping) controls. The numbers of activated cholinergic central canal cluster cells and partition neurons were higher in both step-trained and nontrained rats than in untreated rats and were higher in nontrained than in step-trained rats. The latter finding suggests that daily treatment with epidural stimulation plus serotonergic agonist treatment without step training enhances the excitability of a broader cholinergic interneuronal population than does step training. The numbers of activated interneurons in laminae II-VI of lumbar cross-sections were higher in both step-trained and nontrained rats than in untreated rats, and they were hig...Continue Reading

References

Jun 10, 1983·The Journal of Comparative Neurology·S Nicolopoulos-Stournaras, J F Iles
Dec 6, 2002·Journal of Neurophysiology·W K TimoszykD J Reinkensmeyer
Oct 1, 1953·Journal of Neuropathology and Experimental Neurology·H KLUVER, E BARRERA
May 25, 2004·The Journal of Comparative Neurology·Jennifer M WilsonRobert M Brownstone
Sep 24, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eric S Landry, Pierre A Guertin
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andy J FongV Reggie Edgerton
Jan 20, 2006·The European Journal of Neuroscience·Yu WangXiang Yang Chen
Feb 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gareth B MilesRobert M Brownstone
Sep 15, 2007·Journal of Neurophysiology·Yury P GerasimenkoV Reggie Edgerton
Feb 19, 2008·Autonomic Neuroscience : Basic & Clinical·Nephtali MarinaMichael P Gilbey
Jul 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ronaldo M IchiyamaV Reggie Edgerton
Sep 22, 2009·Nature Neuroscience·Grégoire CourtineV Reggie Edgerton
Apr 8, 2011·Annual Review of Neuroscience·Serge Rossignol, Alain Frigon
Dec 12, 2012·Journal of Neurophysiology·Jessica M D'AmicoMonica A Gorassini
May 25, 2013·Journal of Anatomy·Emily C WittsGareth B Miles
Oct 26, 2013·Journal of Neuroengineering and Rehabilitation·Parag GadVictor Reggie Edgerton
May 27, 2014·Frontiers in Integrative Neuroscience·Jessica M D'AmicoMonica A Gorassini
Jul 1, 2014·Journal of Neuroscience Research·Niranjala J K TillakaratneRoland R Roy
Nov 22, 2014·Frontiers in Neural Circuits·Larry M JordanSerge Rossignol

❮ Previous
Next ❯

Citations

Nov 9, 2016·Neuroscience Letters·Caitlin E Hill
Aug 18, 2017·Physiology·Aiva Ievins, Chet T Moritz
Dec 5, 2019·Frontiers in Cellular Neuroscience·Alex M LaliberteTuan Vu Bui
Aug 29, 2019·Frontiers in Cellular Neuroscience·Amr A MahrousSherif M Elbasiouny

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.