PMID: 6172182Dec 28, 1981Paper

Spinal neurons mediate return of substance P following deafferentation of cat spinal cord

Brain Research
A TesslerM E Goldberger

Abstract

Deafferentation of the cat dorsal horn by complete unilateral lumbosacral dorsal rhizotomy produces a loss and subsequent partial recovery of substance P (SP) immunoreactivity as visualized by the peroxidase-antiperoxidase technique. The present experiments aimed to determine whether this return of SP represents a generalized response of all fiber systems afferent to the denervated segments or a more selective response of a specific spinal system. Although a contribution from other sources cannot be excluded by this qualitative immunocytochemical technique, several observations indicate that the return of SP staining depends on interneurons which contain SP immunoreactivity: (1) the amount of SP staining in the chronically deafferented dorsal horn deprived of extrinsic fiber systems is comparable to that seen after deafferentation alone; (2) SP-containing neurons are present within the lumbar segments; and (3) destruction of lumbar neurons by the intraspinal injection of kainic acid abolishes SP staining from the chronically deafferented dorsal horn. From these observations it would appear that the anatomical plasticity of SP-containing fibers in the deafferented dorsal horn is due to the response of a particular system rather ...Continue Reading

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Citations

Mar 18, 2009·Cellular and Molecular Neurobiology·Alexandra DávidováNadezda Lukácová
Jun 10, 1982·Brain Research·M E Goldberger, M Murray
Feb 1, 1990·Journal of Neuroscience Methods·E M Johnson, E Bullitt
Dec 17, 1991·Brain Research. Developmental Brain Research·S D WangM Murray
Jan 1, 1994·Brain Research Bulletin·M BennisA Calas
Apr 27, 2002·British Journal of Pharmacology·Tuan TrangKhem Jhamandas
Aug 1, 1997·Journal of Neurotrauma·E A ZompaC E Hulsebosch
Aug 1, 1997·Journal of Neurotrauma·M D Christensen, C E Hulsebosch
Jan 30, 2007·Experimental Neurology·David W HamptonMatt S Ramer
Sep 1, 1986·Experimental Neurology·J M PeyronnardM Dubreuil
Mar 30, 1999·The Journal of Comparative Neurology·J MarsalaY Taira

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