Spinal nicotinic receptor expression in spontaneously hypertensive rats

Hypertension
I M KhanP Taylor

Abstract

Intrathecal administration of nicotinic agonists previously has been shown to result in exaggerated pressor and heart rate responses as well as greater nociceptive behavior in adult (12-week-old) spontaneously hypertensive rats (SHR) than in age-matched normotensive Wistar-Kyoto rats (WKY). Paradoxical to these augmented responses to nicotinic agonists in SHR, nicotinic receptor number in the spinal cord as measured by cytisine binding sites is lower in adult SHR than normotensive WKY and Sprague-Dawley rats. Using the high-affinity agonist epibatidine, we found similar differences in receptor number between strains in both in vitro ligand binding experiments with spinal cord membranes and in situ autoradiographic analyses. Spinal nicotinic receptor number did not differ in 5-week-old prehypertensive SHR and age-matched WKY; however, receptor numbers were higher in young rats of both strains than in their adult counterparts. Antihypertensive treatment (25 mg/kg per day hydralazine PO) in 6-week-old SHR from 6 to 12 weeks of age markedly reduced the progressive rise in blood pressure yet did not alter nicotinic receptor number compared with untreated rats. Similar treatment of WKY with hydralazine produced a slight fall in blood...Continue Reading

References

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Citations

Jan 27, 2004·Neuroscience Research·Michelle Vincler, James C Eisenach
Nov 17, 2001·Clinical and Experimental Hypertension : CHE·I M KhanP Taylor
Nov 25, 2003·Pharmacology & Toxicology·Mahinda Kommalage, A Urban Höglund
Jan 15, 2005·Progress in Neurobiology·C Gotti, F Clementi
Oct 24, 2003·The Journal of Comparative Neurology·Imran KhanPalmer Taylor
Sep 13, 2003·Acta Anaesthesiologica Scandinavica·M H YoonS W Jeong

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