Spinal NK1 receptors contribute to the increased excitability of the nociceptive flexor reflex during persistent peripheral inflammation

Brain Research
A M ParsonsV S Seybold

Abstract

Hyperalgesia is a characteristic of inflammation and is mediated, in part, by an increase in the excitability of spinal neurons. Although substance P does not appear to mediate fast synaptic events that underlie nociception in the spinal cord, it may contribute to the hyperalgesia and increased excitability of spinal neurons during inflammation induced by complete Freund's adjuvant. We examined the role of endogenous substance P in changes in the excitability of spinal neurons during adjuvant-induced, peripheral inflammation by determining the effect of a selective NK1 receptor antagonist (RP67580) on the nociceptive flexor reflex in adult rats. Experiments were conducted 2 or 3 days after injection of adjuvant. Animals exhibited moderate thermal hyperalgesia at this time. The flexor reflex was evoked by electrical stimulation of the sural nerve and was recorded in the ipsilateral hamstring muscles. The flexor reflex ipsilateral to the inflamed hindpaw was enhanced approximately two-fold compared to the flexor reflex evoked in untreated animals as determined by the number of potentials and the duration of the reflex. The enhanced reflex in adjuvant-treated animals was most likely due to an increase in the excitability of spinal...Continue Reading

Citations

May 15, 2007·Pain·Monique A van RijnJacobus J van Hilten
Dec 16, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Hrishikesh Kumar, Mandar Jog
Aug 14, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jacobus J van Hilten
Mar 17, 2006·Journal of Neurochemistry·V S SeyboldP G Mermelstein
Nov 9, 2018·Frontiers in Neuroscience·Agnes W WongJanet R Keast
Feb 13, 1999·Progress in Neurobiology·M J Millan

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