Spinal NMDA receptor involvement in expansion of dorsal horn neuronal receptive field area produced by intracutaneous histamine

Journal of Neurophysiology
Steven L Jinks, Earl E Carstens

Abstract

Histamine elicits the sensation of itch at the site of skin application as well as alloknesis (itch elicited by innocuous mechanical stimuli) in a surrounding area in humans and expansion of the low-threshold mechanosensitive receptive field area of spinal wide dynamic range (WDR)-type dorsal horn neurons in rats. We presently tested if the histamine-evoked expansion of neuronal receptive field area depends on a spinal N-methyl-D-aspartate (NMDA) receptor-mediated process. In pentobarbital sodium-anesthetized rats, mechanical receptive field areas of single WDR-type dorsal horn neurons were mapped with graded von Frey filaments before and 10 min after intracutaneous (ic) microinjection of histamine (1 microl; 1, 3, or 10%) at a low-threshold site within the receptive field. Intracutaneous microinjection of histamine evoked dose-related increases in firing rate, as well as a dose-dependent expansion in mean receptive field area 10 min after 3 and 10%, but not 1%, histamine doses. When a noncompetitive or competitive NMDA receptor antagonist dizocilpine [MK-801; D(-)-2-amino-5-phosphonovalerate (APV), respectively; 1 microM] was first applied topically to the surface of the spinal cord, there was no significant change in mean rec...Continue Reading

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Citations

Jul 29, 2005·Journal of Neurophysiology·David A BereiterHarumitsu Hirata
Nov 19, 2004·Der Schmerz·R RukwiedC Konrad
Oct 19, 2010·CNS Neuroscience & Therapeutics·Ferda CevikbasAkihiko Ikoma
Dec 17, 2011·Acta Physiologica Hungarica·G HorvathG Benedek
Dec 22, 1999·Journal of Neurophysiology·S L Jinks, E Carstens
Feb 27, 2004·European Journal of Clinical Investigation·H-C TillmannA Schultz
Jul 17, 2016·The European Journal of Neuroscience·Akitoshi InoueSeiji Ito
Aug 21, 2008·British Journal of Anaesthesia·M J SheenS-T Huang

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