Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model

Journal of Neurochemistry
Geneviève RoussyPhilippe Sarret

Abstract

Central administration of the neuropeptide neurotensin (NT) was shown to induce antinociceptive responses both spinally and supraspinally. Although NTS2 receptors play an important role in modulating the activity of spinal neurons, we have recently implicated NTS1 receptors in NT's analgesic effects in acute spinal pain paradigms. The current experiments were thus designed to examine the antinociceptive effects of intrathecal administration of NTS1 agonists in formalin-induced tonic pain in rats. We first established, using immunoblotting and immunohistochemical approaches, that NTS1 receptors were present in small- and medium-sized dorsal root ganglion cells and localized in the superficial layers of the dorsal horn of the spinal cord. We then examined the effects of intrathecal injection of NT (1-15 microg/kg) or NTS1 preferring agonists on the nocifensive response to intraplantar formalin. Both NTS1-agonists, PD149163 (10-120 microg/kg) and NT69L (1-100 microg/kg), dose-dependently attenuated the formalin-induced behaviors. Accordingly, NTS1 agonists markedly suppressed pain-evoked c-fos expression in the superficial, nucleus proprius and neck regions of the spinal dorsal horn. The concomitant administration of PD149163 with...Continue Reading

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Citations

Dec 17, 2011·Journal of Molecular Neuroscience : MN·Pawel LisowskiArtur H Swiergiel
Jun 26, 2010·The Journal of Pharmacology and Experimental Therapeutics·Grace C RossiGavril W Pasternak
Feb 18, 2014·The Journal of Clinical Investigation·Michel DemeulePhilippe Sarret
Apr 17, 2012·Behavioural Brain Research·Kristin E SmithElliott Richelson
Dec 29, 2009·Neuroscience·M LafranceP Sarret
Sep 23, 2011·The European Journal of Neuroscience·Nabila KadiriSylvain Hugel
Jul 8, 2009·Molecular Pain·Geneviève RoussyPhilippe Sarret
Nov 17, 2017·Toxins·James T Daniel, Richard J Clark
Jan 25, 2017·The Journal of Pharmacology and Experimental Therapeutics·Izumi KajiJonathan D Kaunitz
Jun 13, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pascal TétreaultPhilippe Sarret
Dec 10, 2016·Frontiers in Neuroscience·Christelle DevaderJean Mazella
Jun 14, 2020·European Journal of Pharmacology·Pascal TétreaultPhilippe Sarret
Mar 11, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rebecca L BrouillettePhilippe Sarret
Feb 20, 2021·Behavioural Brain Research·Mélanie VivancosPhilippe Sarret
Mar 28, 2017·European Journal of Pharmacology·Élie Besserer-OffroyRichard Leduc
Sep 10, 2020·Journal of Medicinal Chemistry·Simon GonzalezSteven Ballet
Jul 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Magali ChartierPhilippe Sarret
Jul 24, 2018·Journal of Medicinal Chemistry·Marc SousbieÉric Marsault
Mar 16, 2018·ACS Medicinal Chemistry Letters·Marc SousbieÉric Marsault

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