Spinal serotonergic system is partially involved in antinociception induced by Trigonella foenum-graecum (TFG) leaf extract

Journal of Ethnopharmacology
Alireza ParvizpurMohammad Kamalinejad

Abstract

It has been reported that Trigonella foenum-graecum (TFG) extract exerts analgesic, anti-inflammatory and anti-pyretic effects in different experimental models. The major objective of this paper was to investigate the site and mechanism of the analgesia induced by Trigonella foenum-graecum extract. We studied the analgesic effects of different doses of Trigonella foenum-graecum extract after i.p., i.t. and i.c.v. administration in formalin test, using male NMRI rats (200-250 g). Trigonella foenum-graecum extract showed analgesic effects in i.p. (1 g/kg) and i.t. (0.5, 1, and 2 mg/rat) (P < 0.05 in all groups) but not in i.c.v. (1 and 3 mg/rat) administrations. Based on the similarities between the effects of Trigonella foenum-graecum extract with those of nonsteroidal anti-inflammatory drugs (NSAIDs) and the role of 5-HT system in analgesic effects of NSAIDs, we tried to investigate the role of spinal 5-HT system in analgesic effects of Trigonella foenum-graecum extract. After lesioning of spinal 5-HT system by 5,7-dihydroxytryptamine (5,7-DHT), it was shown that the analgesic effect of Trigonella foenum-graecum extract (0.5 and 3 mg/rat) in the second phase of formalin test, was abolished completely and reduced relatively afte...Continue Reading

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Citations

Nov 22, 2005·Journal of Ethnopharmacology·Aliresa ParvizpurMohammad Kamalinejad
Dec 10, 2015·Neurochemical Research·Heitor G Araújo-FilhoJullyana S S Quintans
May 2, 2012·Asian Pacific Journal of Tropical Medicine·Aashish S MoraniPrasad A Thakurdesai
Sep 18, 2017·Current Treatment Options in Gastroenterology·Haider RahmanSeymour Katz

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