PMID: 11932060Apr 5, 2002Paper

Spinal substance P release in vivo during the induction of long-term potentiation in dorsal horn neurons

Pain
A W AfrahE Brodin

Abstract

Long-term potentiation (LTP) in wide dynamic range (WDR) neurons in the dorsal horn has been suggested to contribute to central sensitization and the development of chronic pain. Indirect experimental evidence indicates an involvement of substance P (SP), in this respect. The aim of the present study was to monitor the extracellular level of substance P-like immunoreactivity (SP-LI) in the dorsal horn of the rat during and after induction of LTP in WDR neurons in vivo. Electrophysiological recordings of single (WDR) neurons were performed in parallel with microdialysis in the dorsal horn under urethane-anaesthesia. The amount of SP-LI in the microdialysate was determined by radioimmunoassay. As previously shown, high frequency conditioning stimulation of the sciatic nerve induced an increased firing response of WDR neurons. An increased response to C-fibre stimulation, but not A-fibre stimulation, could be determined. A significant increase of the extracellular level of SP-LI in the dorsal horn was detected during, but not after, induction of LTP. These data suggest that SP may be involved in the induction of LTP by high frequency stimulation. However, the maintenance of spinal LTP following high frequency peripheral nerve stim...Continue Reading

References

Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltG Nilsson
May 19, 1987·Neuroscience Letters·E BrodinU Ungerstedt
Oct 1, 1987·The Journal of Physiology·V L Go, T L Yaksh
Jan 1, 1984·The Journal of Physiology·K Murase, M Randić
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Sep 28, 1998·The European Journal of Neuroscience·J Sandkühler, X Liu
Feb 10, 1999·Regional Anesthesia and Pain Medicine·A I Basbaum
Aug 14, 1999·Brain Research. Brain Research Protocols·H GustafssonE Brodin
Aug 25, 2000·European Journal of Pain : EJP·D G SnijdelaarB J Crul
Oct 26, 2000·Pain·J Sandkühler

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Citations

Aug 26, 2003·Advanced Drug Delivery Reviews·Carl-Olav StillerErnst Brodin
Apr 5, 2007·Reviews in the Neurosciences·Johannes Gjerstad
Mar 12, 2013·Journal of Neurosurgery. Spine·Malte SchroederNils Hansen-Algenstaedt
Nov 28, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Katherine A Mifflin, Bradley J Kerr
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jens M LangoschKlaus Lieb
Jun 21, 2005·Psychoneuroendocrinology·Lars Jørgen RyghArne Tjølsen
May 10, 2015·Neuroscience and Biobehavioral Reviews·Lincoln M TracyMelita J Giummarra
Oct 24, 2007·The Journal of Pain : Official Journal of the American Pain Society·Lisa M ThomsonSue A Aicher
Nov 14, 2006·Behavioral and Cognitive Neuroscience Reviews·James W GrauRajesh C Miranda
Apr 5, 2007·Molecular Pain·Jürgen Sandkühler
Apr 28, 2012·Molecular Pain·Noboru TakiguchiTerumasa Nakatsuka
Mar 30, 2011·Molecular Pain·Ruth RuscheweyhJürgen Sandkühler
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
Oct 5, 2018·Cell and Tissue Research·W Zieglgänsberger

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