Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers

The Journal of Comparative Neurology
Alan R Light, Edward R Perl

Abstract

Single primary afferent myelinated fibers from cutaneous receptors of cat and monkey were functionally identified by recording from the spinal cord with micropipettes filled with horseradish peroxidase (HRP). Relatively slowly conducting fibers (less than 40 m/sec) from high threshold mechanoreceptors (mechanical nociceptors) and two types of low threshold mechanoreceptor (D-hair and field) were selected for staining. Iontophoresis of the HRP and subsequent histochemical reaction stained the axons recorded from and their collaterals, including terminations, for several millimeters. The termination patterns in the two species proved essentially identical. Ipsilaterally, the mechanical nociceptor fibers terminated principally in the dorsal horn's marginal zone and in the ventral parts of the nucleus proprius (lamina V in the cat). Some of these nociceptors also had terminals in the midline just dorsal to the central canal, contralaterally in the marginal zone, and at the base of the opposite nucleus proprius. In contrast, the D-hair primary afferent axons terminated in the dorsal part of the nucleus proprius overlapping into the innermost portion of the substantia gelatinosa. The field receptor fibers terminated predominantly in ...Continue Reading

References

Jan 1, 1978·The Journal of Physiology·A G Brown, R E Fyffe
Apr 1, 1977·The Journal of Comparative Neurology·Miklós Réthelyi
Jan 18, 1974·Brain Research·D Albe-FessardY Lamour
Oct 15, 1968·Experientia·J M Petras
Jun 1, 1967·The Journal of Physiology·P R Burgess, Edward R Perl
Oct 1, 1952·A.M.A. Archives of Neurology and Psychiatry·A A PEARSON
Apr 1, 1964·The Journal of Comparative Neurology·J SZENTAGOTHAI
Jun 1, 1952·The Journal of Comparative Neurology·B REXED
Dec 1, 1967·The Journal of Physiology·A G Brown, A Iggo

Citations

Oct 8, 1998·The Journal of Comparative Neurology·A Malick, R Burstein
May 13, 1999·The Journal of Comparative Neurology·C MorganD E Scott
Jan 1, 1986·Journal of Neural Transmission·U Holzer-PetscheF Lembeck
Sep 22, 2011·Neuroscience Bulletin·Jun Chen
Jun 4, 1987·European Journal of Pharmacology·T DoiY Maki
Jan 1, 1981·Pharmacology & Therapeutics·Donna L Hammond, Tony L Yaksh
Apr 1, 1986·Journal of Neuroscience Methods·K L BernardoT A Woolsey
Apr 1, 1981·Journal of the Autonomic Nervous System·W C de GroatK Thor
Jun 1, 1994·Trends in Neurosciences·G J GieslerR J Dado
Aug 1, 1993·Progress in Neurobiology·Michael W SalterJ L Henry
May 15, 1986·Neuroscience Letters·S Mense, N R Prabhakar
Sep 1, 1987·Neuroscience·K E Miller, V S Seybold
Sep 1, 1980·Brain Research Bulletin·G A BishopJ S King
Jan 1, 1995·Brain Research Bulletin·Y Ohmori, R Necker
Jun 3, 1999·The Surgical Clinics of North America·L S Sorkin, M S Wallace
Jan 13, 2001·Brain Research. Developmental Brain Research·E N OrlinoP E Phelps
Aug 7, 1998·Brain Research. Developmental Brain Research·W RahmanA H Dickenson
Mar 5, 1999·Brain Research. Developmental Brain Research·J S ParkM Yoshimura
Sep 22, 2000·Peptides·Timothy D MoranP A Smith
Apr 23, 2004·European Journal of Pain : EJP·Deolinda Lima
Dec 21, 2006·Nature Reviews. Neuroscience·Edward R Perl
Nov 12, 2010·Nature Reviews. Neuroscience·Andrew J Todd
Aug 22, 2000·British Journal of Pharmacology·M K PatelK Lee
Aug 25, 2000·European Journal of Pain : EJP·D G SnijdelaarB J Crul
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y De KoninckA C Cuello
Aug 1, 1997·Journal of Neurotrauma·M D Christensen, C E Hulsebosch
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·M MichaelisW Jäenig
Aug 1, 1996·The European Journal of Neuroscience·Gary R Lewin, L M Mendell
Aug 16, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Megan N MurphyScott A Smith
Jan 29, 2005·Brain, Behavior and Evolution·Stéphanie LamoureuxThérèse Cabana
Dec 23, 2011·Development·Y Albert PanAlexander F Schier
Nov 8, 2007·PloS One·Loïs S MiraucourtDaniel L Voisin
Aug 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simona NeumannA I Basbaum
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jie LiMark L Baccei
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claire A Daniele, Amy B MacDermott
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Go KatoA M Strassman
Feb 1, 2007·Neuropsychiatric Disease and Treatment·Joseph G McGivern
Dec 19, 2013·ISRN Neurology·Pablo R Brumovsky
Jan 31, 2015·Cell·Steeve BouraneMartyn Goulding
Jun 1, 1982·The Journal of Comparative Neurology·Miklós RéthelyiEdward R Perl
Mar 23, 2011·Progress in Neurobiology·Edward R Perl
Sep 11, 2008·Neuroscience Letters·Miklós RéthelyiCsaba Boros
Dec 13, 2006·Neuroscience Research·Toru TaguchiKazue Mizumura
Aug 24, 2007·Pain Practice : the Official Journal of World Institute of Pain·Yoshi F Shen, Greg Goddard
Jun 25, 2010·The Journal of Comparative Neurology·Steve DavidsonG J Giesler
Apr 17, 2014·Journal of Magnetic Resonance Imaging : JMRI·Torge RempeJanne Gierthmühlen
Mar 19, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·William OlsonWenqin Luo
Jul 16, 2013·The Journal of Comparative Neurology·Michael C Cagle, Marcia G Honig
Jan 1, 1997·Archives of Physical Medicine and Rehabilitation·G A Mellick, L B Mellick
Mar 30, 2004·The Journal of Surgical Research·Edward H KimKimberly S Kirkwood
Sep 19, 2006·Molecular and Cellular Neurosciences·Sandra RebeloDeolinda Lima
Jan 1, 1988·Annals of the New York Academy of Sciences·W D Willis
Aug 15, 2006·Neuroscience Letters·Jun-Ho LaJaehee Han
Sep 13, 2005·Brain Research. Developmental Brain Research·Ki Jun KimPamela Pierce Palmer
Oct 4, 2005·Brain Research·Zafer Soygüder
May 24, 2014·Neuron·Francis P McGloneHakan Olausson
Apr 22, 2015·Journal of Diabetes and Its Complications·Hoang Thi Thanh NguyenSeong Kyu Han
Nov 1, 1989·Pain·L García-LarreaF Mauguière
Apr 29, 2006·Pain·Takeshi TsujiRyusuke Kakigi
Nov 14, 1983·The American Journal of Medicine·S Mense
Jul 6, 2016·The Journal of Physiology·Emanuel N van den BroekeAndré Mouraux
Sep 8, 2016·Neuroscience·Matilde Cordero-ErausquinSylvain Hugel
Oct 25, 2016·Journal of Integrative Neuroscience·Özlem KirazlıSafiye Çavdar
Mar 14, 2007·Journal of Neurophysiology·Peggy Mason
Dec 4, 2003·The Journal of Comparative Neurology·Caroline Gauriau, Jean-François Bernard
Apr 6, 2004·The Journal of Comparative Neurology·Francisco J AlvarezStephen P Schneider
Apr 20, 2004·The European Journal of Neuroscience·Alain WodaPhilippe Luccarini
Aug 16, 2000·The Journal of Physiology·P K WinchesterJ H Mitchell
Sep 14, 2004·Journal of Neurobiology·Gary R Lewin, Rabih Moshourab
Jan 28, 2009·European Journal of Pain : EJP·Lone Knudsen, Peter D Drummond
Aug 7, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sandra RebeloDeolinda Lima
Mar 13, 2008·The Journal of Comparative Neurology·C Jeffery WoodburyH R Koerber
Feb 20, 2009·Anesthesia and Analgesia·Linda S BarterJoseph F Antognini
Oct 30, 1995·The Journal of Comparative Neurology·M J GentleR J Sterling
Nov 1, 1983·The Journal of Comparative Neurology·R L NahinG J Giesler
Apr 20, 1983·The Journal of Comparative Neurology·M F JacquinR W Rhoades
Sep 22, 2005·The Journal of Comparative Neurology·Adam W Hantman, Edward R Perl
Jan 1, 1995·Somatosensory & Motor Research·H H WillcocksonAlan R Light
Jan 1, 1991·Somatosensory & Motor Research·W M PannetonM F Jacquin
May 3, 2013·Physiology·Stefan G Lechner, Gary R Lewin
Apr 16, 2019·Pain·Volodymyr KrotovNana Voitenko
Jun 13, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven W CoppMarc P Kaufman
Dec 25, 2019·ELife·Andrew G MarshallFrancis P McGlone
Feb 19, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T M Jessell, J Dodd
Feb 27, 2020·Journal of Oral Science·Masayuki Kobayashi, Yuka Nakaya
May 2, 2003·The Journal of Comparative Neurology·Li-Jun LingYasuo Sugiura
Jan 1, 1994·Autoimmunity·L AloeR Levi-Montalcini
Jul 1, 1986·The Journal of the American Paraplegia Society·P A Young
May 15, 1995·The Journal of Comparative Neurology·K Mirnics, H R Koerber
Oct 6, 1997·Journal of Neurophysiology·K Mirnics, H R Koerber
Aug 5, 2003·Canadian Journal of Physiology and Pharmacology·Fuad A AbdullaPeter A Smith
Jun 26, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Patrick L Stemkowski, Peter A Smith
Apr 1, 2017·Frontiers in Molecular Neuroscience·Yinth A Bernal SierraGary R Lewin
Dec 20, 2017·Current Physical Medicine and Rehabilitation Reports·Ann S Choe
Jun 8, 1993·The Journal of Comparative Neurology·S S KanekarJ D Coulter
Nov 15, 1993·The Journal of Comparative Neurology·F L RiceJ Arvidsson
Feb 22, 1985·The Journal of Comparative Neurology·T UeyamaR Matsushima
May 2, 2003·The Journal of Comparative Neurology·Alan R Light, Edward R Perl
Nov 8, 1993·The Journal of Comparative Neurology·E P MtuiD A Ruggiero
May 22, 1989·The Journal of Comparative Neurology·K ChungR E Coggeshall
Nov 1, 2019·The Chinese Journal of Physiology·Thao Thi Phuong NguyenSeong Kyu Han
Apr 1, 2020·Journal of Oral Science·Yong-Chul Bae, Atsushi Yoshida
Jul 13, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hoang Thi Thanh NguyenSoo Joung Park
Oct 9, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·David I Hughes, Andrew J Todd

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Anthropoidea
Felis catus
Electrophysiology (Science)
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Myelinated Nerve Fiber
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