Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus)

The American Journal of Surgical Pathology
K J SmithJ H Graham


We report on the clinical and pathologic features of 32 lesions diagnosed as malignant spindle cell and epithelioid cell nevus (S&E nevus). Because of the clinical or initial histopathologic diagnosis of malignant melanoma, six patients had lymph node dissection. Three of these patients also had an enlarged lymph node. In all six cases, metastatic spindle or epithelioid cells were found in at least one of the resected lymph nodes. Of the 30 patients with follow-up information, including all six patients with lymph node metastases, all are alive and well. No recurrences or further metastases have been found. On histopathologic reevaluation, all the lesions had features of S&E nevi. Study of these cases suggests that although some lesions with features of S&E nevi may involve local lymph nodes, widespread metastases do not result.


Mar 12, 2013·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·D P JoyceA D K Hill
Feb 20, 1999·Journal of the American Academy of Dermatology·A Spatz, R L Barnhill
Jun 15, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·María C Garrido-RuizJosé Luis Rodríguez Peralto
Oct 7, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Payal KapurMai P Hoang
Jun 27, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Douglas R FullenStephen B Gruber
May 8, 2002·Pediatric Dermatology·Philip E LeBoit
May 8, 2002·Pediatric Dermatology·Yesim GurbuzNesimi Buyukbabani
Mar 9, 1995·The New England Journal of Medicine·P I CeballosM C Mihm
Feb 24, 2001·The American Journal of Dermatopathology·P A GrobenW L White
Aug 2, 2001·The American Journal of Dermatopathology·P E LeBoit
Jan 25, 2003·The American Journal of Dermatopathology·Philip E LeBoit
Jan 5, 2002·The American Journal of Surgical Pathology·Christina M LohmannKlaus J Busam
Apr 30, 2002·The American Journal of Surgical Pathology·Jeff D HarvellPhilip E LeBoit
Apr 22, 2003·Magyar onkologia·Zsolt Orosz
Jun 20, 2002·Advances in Anatomic Pathology·Wolter J Mooi
Aug 27, 2005·The American Journal of Dermatopathology·Carmelo Urso
Aug 27, 2005·The American Journal of Dermatopathology·Michael Piepkorn
Feb 4, 2006·The American Journal of Dermatopathology·Raymond L Barnhill
Mar 26, 2009·The American Journal of Dermatopathology·Celia RequenaEvaristo Sánchez Yus
Mar 11, 2011·The American Journal of Dermatopathology·Raymond L BarnhillClaire Lugassy
Apr 12, 2011·The American Journal of Dermatopathology·Wolfgang Weyers
Sep 24, 2009·The American Journal of Surgical Pathology·Rajni V MandalArtur Zembowicz
Sep 1, 1992·International Journal of Dermatology·H G SkeltonG P Lupton
May 1, 1993·International Journal of Dermatology·C B KoH P Bury
Jul 1, 1996·Pediatric Dermatology·Z GhorbaniA H Mehregan
Jan 4, 2012·Pediatric Dermatology·Felecia CerratoBrian I Labow
Oct 29, 2004·Journal of Clinical Pathology·K S CulpepperP H McKee
Jul 27, 2000·Journal of Clinical Pathology·S L Edwards, K Blessing
Aug 13, 2009·Annals of Surgical Oncology·Robert Howman-GilesJohn F Thompson
Mar 30, 2016·Pathology·Daniela MassiMario Mandalà
Oct 1, 2013·Dermatologic Clinics·Gerardo FerraraGiuseppe Argenziano
Oct 1, 2013·Dermatologic Clinics·Elvira MoscarellaIris Zalaudek
Oct 27, 2004·Cancer·Melissa GillJülide Tok Celebi
Dec 20, 2011·American Journal of Surgery·Sarah J Hill, Keith A Delman
Nov 16, 2011·Journal of the American Academy of Dermatology·Su LuoHensin Tsao
May 1, 1991·Pathology, Research and Practice·S B González
Apr 19, 2011·Journal of the American Academy of Dermatology·Daniela MassiVincenzo Canzonieri
Apr 28, 2004·The American Journal of Pathology·Janet L MaldonadoBoris C Bastian
Nov 3, 2009·Clinics in Dermatology·Hideko Kamino

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