Spindle Cell Carcinoma of the Larynx: A Confusing Diagnosis for the Pathologist and Clinician

Case Reports in Otolaryngology
Asli BostanciMurat Turhan

Abstract

Laryngeal spindle cell carcinoma (SpCC) is an uncommon subtype of squamous cell carcinoma which represents 0.5% of all laryngeal squamous cell carcinomas. It is a biphasic tumor consisting of the combination of a malignant mesenchymal spindle cell component and a squamous cell component that includes dysplasia, carcinoma in situ, or invasive carcinoma. Although it has aggressive biological features, the probability of making a diagnosis in the early stages is high as it often leads to obstructive symptoms in the early period. Due to its low incidence, there is no clear consensus on prognostic factors and optimal treatment strategies yet. In this paper, a 60-year-old laryngeal SpCC case that was effectively treated with wide local excision followed by adjuvant radiotherapy was presented with the literature.

References

Jan 29, 2002·The American Journal of Surgical Pathology·Lester D R ThompsonDennis K Heffner
Mar 11, 2003·Acta Oto-laryngologica·Gino MarioniGiuseppe Altavilla
Jun 25, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·James S LewisSamir El-Mofty
May 23, 2015·The Laryngoscope·Pariket M DubalJean Anderson Eloy

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Citations

Aug 6, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Andrea ColizzaMarco de Vincentiis

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Methods Mentioned

BETA
biopsy

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