Spindle cell carcinoma of the larynx.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
H Hellquist, J Olofsson

Abstract

The clinicopathological features of 14 laryngeal neoplasms consisting of spindle-shaped cells are presented. Light microscopy showed a variety of morphological patterns from that of pleomorphic sarcoma and fibrosarcoma to more loose vascular patterns. Immunohistochemistry revealed that the spindle-shaped cells had a positive keratin immunoreactivity in 8 of 14 cases, and also that some cases had a dual expression of keratin and vimentin filaments. Electron microscopy showed that spindle-shaped cells had epithelial ultrastructures. The results support the hypothesis that the spindle cell carcinomas are true carcinomas with mesenchymal metaplasia and that the spindle-shaped cells are part of the neoplasm and not benign, reactive fibroblasts. These lesions occurred mainly on the true vocal cords in elderly patients. The neoplasms were nearly all polypoid, and many also ulcerated. There is no significant difference in clinical behaviour between laryngeal spindle cell carcinomas and ordinary squamous cell carcinomas of the larynx, and the same treatment policy is therefore advocated. Being polypoid and therefore able to be surgically removed with relative ease, they may even present a more favourable clinical course.

References

Oct 1, 1979·The American Journal of Surgical Pathology·K H LasserJ Higgins
Jun 1, 1978·The American Journal of Surgical Pathology·R Y OsamuraT Mitomi
Mar 1, 1976·Cancer·T MatsusakaM Enjoji
Jun 1, 1985·The American Journal of Surgical Pathology·M MiettinenH Damjanov
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Hellquist, L Michaels
May 1, 1987·The American Journal of Surgical Pathology·G L EllisV J Hyams
Sep 1, 1988·Acta Oto-laryngologica·J W MeijerG P Vooys
Mar 1, 1973·American Journal of Clinical Pathology·J R GoellnerL H Weiland
Aug 1, 1982·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M MiettinenI Virtanen
Jun 1, 1984·The American Journal of Surgical Pathology·D R ChaseJ M Langloss
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·J CaselitzM Osborn
Sep 1, 1984·Journal of Clinical Pathology·C A MakinW F Bodmer
Jul 1, 1984·Acta Oto-laryngologica·M KatholmP Bretlau
Dec 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·G L Ellis, R L Corio

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Citations

Jan 29, 2002·The American Journal of Surgical Pathology·Lester D R ThompsonDennis K Heffner
Aug 10, 2002·The American Journal of Surgical Pathology·M Ali Ansari-LariWilliam H Westra
Apr 2, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Fernando LópezAlfio Ferlito
May 1, 1995·The Journal of Laryngology and Otology·L T HansenJ Moesner
Jun 1, 1994·The Journal of Laryngology and Otology·M CassidyM Leader
Mar 25, 2020·Advances in Anatomic Pathology·Andrew M Bellizzi

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