PMID: 2474578Jul 1, 1989

Spindle-cell carcinoma of the oral cavity and larynx. Immunohistochemical aspects

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
P J SlootwegH Lubsen


Five cases of monophasic and 7 cases of biphasic spindle-cell carcinomas were analyzed immunohistochemically for the presence of vimentin and keratin type intermediate filaments in the pleomorphic spindle cells. Vimentin reactivity proved to be a consistent feature but keratin reactivity was more variable, this latter filament being lost in two cases initially presenting as pure squamous cell carcinomas showing dedifferentiation towards a pure monophasic spindle-cell tumour when recurring. The converse was also noted: acquisition of keratin in a monophasic spindle-cell tumour that recurred as squamous cell carcinoma. These results were considered to support the concept that spindle-cell tumours of the upper aerodigestive tract are a peculiar type of carcinoma and not a product of a pluripotent stem cell exhibiting bidirectional differentiation. Diagnostic implications are as follows: keratin positivity in a spindle-cell tumour substantiates its carcinomatous nature but its absence does not rule out a diagnosis of spindle-cell carcinoma.


Dec 10, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·A A SanabreG R Martin
Nov 27, 2004·Head & Neck·Michael L CohnAdel K El-Naggar
May 1, 1995·The Journal of Laryngology and Otology·L T HansenJ Moesner
Apr 7, 2006·Journal of Orthopaedic Surgery·A LesicM Atanackovic

Related Concepts

Neoplasm Recurrence, Local
Carcinoma, Spindle-Cell
VIM gene
Pluripotent Stem Cells
Benign Neoplasm of Larynx
Laryngeal Diseases

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