Spindle cell oncocytoma of the adenohypophysis: two case reports and a review of the literature

Molecular Medicine Reports
Qingchun MuHaiyan Huang

Abstract

Spindle cell oncocytoma (SCO) of the adenohypophysis is a rare tumor in the sellar region. Due to its rarity, little information is available regarding SCO. It is often misdiagnosed as another type of sellar tumor. In the present study, two cases of SCO were reported. One patient was a 35-year-old female presenting with decreased visual acuity, amenorrhea and lactation. The other patient was a 62-year-old female with no clear symptoms or signs. Cranial magnetic resonance imaging (MRI) revealed a suprasellar mass with marked homogeneous enhancement in the two cases. A craniotomy was performed to completely resect the tumors. The tumors were immunopositive for vimentin, epithelial membrane antigen (EMA), S-100 and thyroid transcription factor-1 (TTF-1). The tumors were pathologically diagnosed as SCO. No recurrence occurred during the follow-up period of 15-21 months. In the present study, the literature was reviewed and the clinical data, imaging features, intraoperative findings and recurrence of 24 cases were analyzed in the literature as well as the present two cases. The average age of the SCO patients was 58.5 years and no gender preference was observed for the disease. The tumor exhibited homogeneous enhancement on the MRI...Continue Reading

References

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Citations

Jun 21, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Akash SaliAtul Goel
Nov 30, 2018·Journal of Neurosurgery·Alexandra M Giantini LarsenEdward R Laws
Feb 20, 2019·The Journal of Clinical Endocrinology and Metabolism·Gregory A KaltsasAshley Grossman
Mar 10, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Shun YamamuroAtsuo Yoshino
Aug 19, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Rie SaitoAkiyoshi Kakita
Mar 14, 2019·Reviews in Endocrine & Metabolic Disorders·Fernando Guerrero-PérezCarles Villabona
Nov 20, 2020·Journal of Neuropathology and Experimental Neurology·Valeria BarresiAldo Scarpa
Jan 22, 2021·Neurosurgery·Peter J KobalkaAline P Becker

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Methods Mentioned

BETA
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hormone replacement therapy
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