Spindle cell sarcoma of the kidney with ganglionic elements (malignant ectomesenchymoma) associated with chromosomal abnormalities and a review of the literature

Journal of Pediatric Hematology/oncology
R E GoldsbyT J Pysher

Abstract

Malignant ectomesenchymomas are tumors that exhibit both mesenchymal and neuroectodermal elements (1). We report a case thought to represent a malignant ectomesenchymoma arising in the kidney with cytogenetic abnormalities that may provide insight into the biologic basis for this unusual tumor. We discuss the clinical features, histopathologic findings, cytogenetics, treatment, and outcome of a child with a malignant ectomesenchymoma arising in the kidney. An asymptomatic 16-month-old boy had a large abdominal mass. The resected tumor contained sheets of spindled cells that expressed mesenchymal markers and cartilaginous differentiation, interspersed with clusters of ganglion cells that expressed neural markers. No blastemal or epithelial elements were demonstrated. Cytogenetic analysis of the tumor revealed a hyperdiploid count with multiple numerical and structural abnormalities, including a translocation between chromosomes 12 and 15. In addition to the surgical resection, the patient was successfully treated with adjuvant chemotherapy and local radiation therapy. This is the first report of which we are aware of an ectomesenchymoma arising within the kidney. A subset of malignant ectomesenchymomas may be related to the Ewin...Continue Reading

References

Jul 1, 1992·The British Journal of Ophthalmology·T H MatskoJ C Orcutt
Dec 1, 1974·Journal of Pediatric Surgery·J B Beckwith
Mar 1, 1971·Journal of Neurosurgery·J L Holimon, W I Rosenblum
Sep 1, 1982·The American Journal of Surgical Pathology·M M GrimesW A Blanc
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histopathology·C CozzuttoR Bandelloni
Jan 1, 1982·Ultrastructural Pathology·D SchmidtN Jaffe
Oct 15, 1995·Cancer Genetics and Cytogenetics·M LoweryA Brothman
Jan 1, 1996·CA: a Cancer Journal for Clinicians·D M GreenP R Thomas

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Citations

Aug 6, 2002·Survey of Ophthalmology·Peter PaikosFoteini Tzortzatou
Oct 18, 2002·Histopathology·G RossiA Maiorana
Feb 16, 2005·Cancer·Eva Steliarova-FoucherPeter Kaatsch
Mar 1, 2005·International Journal of Surgical Pathology·Orit OppenheimerRichard Gorlick
Oct 11, 2017·International Journal of Surgical Pathology·Brannan B GriffinNicoleta C Arva
Sep 27, 2007·The American Journal of Surgical Pathology·Gordan M VujanićJ Bruce Beckwith
Nov 29, 2007·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Giuseppe FlorisRaf Sciot
Mar 25, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Swati MahajanTripti Nakra
Dec 7, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Neil J SebireR Anthony Risdon
May 6, 2020·World Journal of Clinical Cases·Jsun-Liang KaoChih-Chung Shiao
Sep 30, 1999·Ultrastructural Pathology·V EdwardsM J Phillips
Feb 18, 2021·Virchows Archiv : an International Journal of Pathology·Ben DavidsonBodil Bjerkehagen
Aug 10, 2020·Journal of Pediatric Hematology/oncology·Tooba RashidMichael D Deel

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