PMID: 21252629Jan 22, 2011

Spindly switch controls anaphase: spindly and RZZ functions in chromosome attachment and mitotic checkpoint control

Cell Cycle
Marin Barisic, Stephan Geley

Abstract

Spindly is a coiled-coil domain containing protein, also known as CCDC99, that is an important regulator of the mitotic checkpoint. It belongs to a functionally conserved family of proteins that controls the localization and function of cytoplasmic dynein at kinetochores. At kinetochores Spindly interacts with the RZZ (Rod/ZW10/Zwilch) complex and is required for the recruitment of cytoplasmic dynein to kinetochores. Loss of Spindly results in loss of kinetochore dynein functions, which impairs poleward chromosome movements and mitotic checkpoint inactivation. In addition, Spindly regulates the establishment of stable microtubule attachments via regulation of the RZZ complex. Thus, Spindly couples dynein-mediated poleward chromosome movements to the establishment of stable microtubule attachments and subsequent mitotic checkpoint inactivation and provides an important switch for the control of mitosis.

Citations

Sep 22, 2012·Journal of Biochemistry·Kozo Tanaka
May 30, 2014·Chromosoma·J A Raaijmakers, R H Medema
Jul 4, 2012·Cellular and Molecular Life Sciences : CMLS·Kozo Tanaka
Apr 1, 2015·The Journal of Cell Biology·Devinderjit K MoudgilGordon K T Chan
Dec 5, 2015·Frontiers in Cell and Developmental Biology·Jack W C ChenJames G Wakefield
Sep 24, 2015·Cell Cycle·Marin Barisic, Helder Maiato
Oct 6, 2015·Annual Review of Cell and Developmental Biology·Michael A CianfroccoSamara L Reck-Peterson
Oct 11, 2014·Nature Reviews. Molecular Cell Biology·Nitobe London, Sue Biggins
Jan 1, 2015·Molecular & Cellular Oncology·Tiziana Lischetti, Jakob Nilsson

Related Concepts

Spindly protein, human
Anaphase
Carrier Proteins
Chromosomes
Dynein Intermediate Chains
HeLa Cells
Microtubules
Signal Transduction
Kinetochores
Cell Cycle Proteins

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