Spine Surgery in Patients with Metastatic Breast Cancer: A Retrospective Analysis

World Neurosurgery
Stefano TeleraAlessandra Fabi

Abstract

Pathologic or iatrogenic symptomatic spinal lesions are common in metastatic breast cancer. Given the longer duration of overall survival provided by modern oncologic therapies, a prompt and effective treatment of such lesions may have a significant impact on patient's quality of life, improving pain and preventing deterioration of neurologic functions. A retrospective review was conducted on patients with breast cancer operated to the spine between 2005 and 2013. The series includes 41 patients and 57 vertebral levels treated (4 cervical, 35 dorsal, and 18 lumbar). There were 28 patients who received palliative surgery and 13 who received excisional surgery, according to their clinical conditions, Spinal Instability Neoplastic Score, and Tokuhashi scores. Of the 41 patients, 38 presented with a median survival of 50 months (95% confidence interval [CI], 39-61), still preserving a Karnofsky Performance Status Scale score ≥60 and a retained ability to ambulate independently. The median overall survival after the first spine surgery was also 50 months (95% CI, 35-65), suggesting that in this cohort of patients, a reasonable quality of life was preserved almost to the end of their clinical history. In patients treated with palliat...Continue Reading

References

Jan 1, 1995·Journal of Neuro-oncology·F E LandreneauP F Ferson
Jan 12, 1999·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·H Pascal-MoussellardJ Sénégas
Mar 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T A PlunkettR D Rubens
Sep 30, 2003·Medical Oncology·Markus Wenger
Oct 11, 2005·Cancer·Peter C GersztenWilliam J Vogel
Nov 4, 2005·Journal of Neurosurgery. Spine·Peter C GersztenWilliam J Vogel
Apr 5, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Joseph A ShehadiZiya L Gokaslan
May 9, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Daniel M SciubbaJoseph A Shehadi
Aug 7, 2013·Yonsei Medical Journal·Sung Gwe AhnHy-De Lee
Sep 4, 2013·Clinical & Experimental Metastasis·Patricia L ZadnikDaniel M Sciubba
Nov 15, 2013·Clinical Epidemiology·Mette SøgaardMette Nørgaard
May 16, 2014·International Journal of Cancer. Journal International Du Cancer·Aju Mathew, Adam Brufsky
Jul 1, 2014·World Journal of Radiology·Fernando Ruiz SantiagoMiguel Pajares López
Aug 13, 2014·World Journal of Clinical Oncology·Derek G JuDaniel M Sciubba
Aug 15, 2014·World Neurosurgery·Emilie Chan-SengNicolas Lonjon

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Citations

Sep 13, 2017·Radiation Oncology·Johannes RoeschMatthias Guckenberger

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