Jan 15, 2015

Spine synapse remodeling in the pathophysiology and treatment of depression

Neuroscience Letters
Catharine H Duman, Ronald S Duman

Abstract

Clinical brain imaging and postmortem studies provide evidence of structural and functional abnormalities of key limbic and cortical structures in depressed patients, suggesting that spine synapse connectivity is altered in depression. Characterization of the cellular determinants underlying these changes in patients are limited, but studies in rodent models demonstrate alterations of dendrite complexity and spine density and function that could contribute to the morphological and functional alterations observed in humans. Rodent studies demonstrate region specific effects in chronic stress models of depression, including reductions in dendrite complexity and spine density in the hippocampus and prefrontal cortex (PFC) but increases in the basolateral amygdala and nucleus accumbens. Alterations of spine synapse connectivity in these regions are thought to contribute to the behavioral symptoms of depression, including disruption of cognition, mood, emotion, motivation, and reward. Studies of the mechanisms underlying these effects demonstrate a role for altered brain derived neurotrophic factor (BDNF) signaling that regulates synaptic protein synthesis. In contrast, there is evidence that chronic antidepressant treatment can blo...Continue Reading

Mentioned in this Paper

Limbic System
Prefrontal Cortex
Depressed - Symptom
Autopsy
Neurons
Recombinant Brain-Derived Growth Factors
Brain-Derived Neurotrophic Factor Measurement
Mental Suffering
BDNF gene
Brain-Derived Neurotrophic Factor

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