PMID: 11313448Apr 21, 2001Paper

Spino-bulbo-spinal pathway mediating vagal modulation of nociceptive-neuroendocrine control of inflammation in the rat

The Journal of Physiology
F J MiaoJ D Levine

Abstract

Stimulation of nociceptors by intradermal capsaicin produces depression of bradykinin (BK)-induced synovial plasma extravasation (PE) that is markedly enhanced by subdiaphragmatic vagotomy. This depression is mediated by the adrenal medullae, a propriospinal pathway between the afferent nociceptive input and preganglionic neurones projecting to the adrenal medullae, and a spino-bulbo-spinal pathway. Here we investigated the role of spinal ascending and descending pathways in the interaction between noxious and vagal afferent inputs, leading to inhibition of BK-induced PE mediated by the adrenal medullae. Nociceptors in the paw were activated by capsaicin and depression of BK-induced PE was measured in rats with intact or cut subdiaphragmatic vagus nerves. After cutting the dorsolateral funiculus (DLF) contralateral to the stimulated hindpaw (segmental level C5/C6 and T8/T9), depression of BK-induced PE was weak or absent both in rats with intact vagus nerves and in vagotomised rats, suggesting that an ascending excitatory pathway was interrupted. After cutting the DLF ipsilateral to the stimulated hindpaw, depression of BK-induced PE was already markedly enhanced, even in the absence of vagotomy. Ipsilateral DLF lesion (L2/L3) ...Continue Reading

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Citations

Jan 22, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Feb 18, 2014·Autonomic Neuroscience : Basic & Clinical·Wilfrid Jänig, Paul G Green
Jul 9, 2004·Annals of the New York Academy of Sciences·B MravecR Kvetnansky
Aug 30, 2005·European Journal of Pain : EJP·Annette KirchnerFrank Birklein
Sep 12, 2008·The European Journal of Neuroscience·Olayinka A DinaJon D Levine
Dec 18, 2003·The Journal of Physiology·Frederick Jia-Pei MiaoJon D Levine
Oct 13, 2005·Journal of Neuroendocrinology·B MravecM Palkovits
Jul 21, 2006·Annals of the New York Academy of Sciences·Jon D LevinePaul G Green
Jul 8, 2008·Progress in Neurobiology·Nayef E Saadé, Suhayl J Jabbur

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