Spino-olivary projections in the rat are anatomically separate from postsynaptic dorsal column projections

The Journal of Comparative Neurology
Charlotte R FlavellBridget M Lumb

Abstract

The gracile nucleus (GN) and lateral part of rostral dorsal accessory olive (rDAO) are important relays for indirect, postsynaptic dorsal column, and direct ascending pathways, respectively, that terminate as climbing fibers in the "hindlimb-receiving" parts of the C1 and C3 zones in the cerebellar cortex. While the spinal cells of origin of that project to GN and rDAO are from largely separate territories in the spinal cord, previous studies have indicated that there could be an area of overlap between these two populations in the medial dorsal horn. Given the access of these two ascending tracts to sensory (thalamic) versus sensorimotor (precerebellar) pathways, the present study therefore addresses the important question of whether or not individual neurons have the potential to contribute axons to both ascending pathways. A double-fluorescent tracer strategy was used in rats (red Retrobeads and Fluoro-Ruby or green Retrobeads and Fluoro-Emerald) to map the spatial distribution of cells of origin of the two projections in the lumbar spinal cord. The two pathways were found to receive input from almost entirely separate territories within the lumbar cord (levels L3-L5). GN predominantly receives input from lamina IV, while rD...Continue Reading

References

Jan 18, 1977·Experimental Brain Research·A Rustioni, A B Kaufman
Mar 1, 1979·Brain : a Journal of Neurology·A RustioniS O'Neill
Jul 2, 1979·Experimental Brain Research·C F Ekerot, B Larson
Feb 1, 1971·Archives of Neurology·M G Murphy, J L O'Leary
Feb 10, 1984·The Journal of Comparative Neurology·H H Molinari
Feb 1, 1984·Journal of Neurophysiology·G J GieslerA M Madsen
Sep 7, 1984·Neuroscience Letters·J de PommeryD Menétrey
Apr 1, 1983·The Journal of Comparative Neurology·R GellmanA R Gibson
Mar 3, 1998·The Journal of Comparative Neurology·M L McCurdyA R Gibson
May 17, 2002·The Journal of Physiology·Richard Apps, Stephen Lee
May 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nadia L Cerminara, John A Rawson
Apr 2, 2005·Nature Reviews. Neuroscience·Richard Apps, Martin Garwicz
Aug 16, 2005·Journal of Chemical Neuroanatomy·Ken W S Ashwell, George Paxinos

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