PMID: 8946062Nov 22, 1996Paper

Spinocerebellar mossy fiber terminal topography in the NR2C/PKC gamma double mutant cerebellum

Brain Research. Developmental Brain Research
Z JiM W Vogel

Abstract

The spatiotemporal expression patterns of the NR2C subunit of the NMDA receptor and PKC gamma isoform during cerebellar development suggests that both proteins are involved in the molecular mechanisms of synaptogenesis. However, the topographic distribution of WGA-HRP labeled spinocerebellar mossy fiber terminals in NR2C/PKC gamma double mutants (n = 4) appears similar to controls (n = 3). While the results do not rule out a role for NR2C receptor subunits and the PKC gamma isoform in cerebellar synaptogenesis, they indicate that neither is necessary for the formation or maintenance of normal spinocerebellar mossy fiber afferent maps.

References

Sep 1, 1992·Trends in Neurosciences·Y Ben-AriP Bregestovski
Mar 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C Sotelo, M Wassef
Jul 15, 1985·The Journal of Comparative Neurology·M L Arsénio Nunes, C Sotelo
May 8, 1994·The Journal of Comparative Neurology·M W Vogel, J Prittie
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·R A HarrisJ M Wehner
Mar 24, 1994·Nature·M FarrantS G Cull-Candy
May 1, 1996·Trends in Neurosciences·J N Crawley

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.