Oct 1, 1989

Spinocerebellar projections from spinal border cells in the cat as studied by anterograde transport of wheat germ agglutinin-horseradish peroxidase

The Journal of Comparative Neurology
M Matsushita, H Yaginuma

Abstract

The cerebellar projections of spinal border cells, which give rise to crossed ascending axons, were studied in the lower lumbar segments by the anterograde transport of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) in the cat. Prior to the injections, the spinal cord was lesioned rostral and ipsilateral to the WGA-HRP injections to eliminate labeling of the ipsilaterally ascending axons. Following injections of WGA-HRP into the L4-L6 segments, labeled terminals were seen in sublobules Ib-Vf of the anterior lobe, sublobules VIf-VIe, lobule VIII, the paramedian lobule, and crus II. More than 90% of the total number of labeled terminals were in the anterior lobe; the projections were predominantly ipsilateral to their cells of origin (about 90% or more labeled terminals of the total number in each of sublobules IIb-Va). Many labeled terminals were seen ipsilaterally in sublobules IIb (11.1-17.5% of the total number), IIIa (11.7-12.9%), IIIb (16.1-17.6%), IVa (8.8-10.8%), IVb (6.2-10.5%), and Va (9.7-10.3%). In the posterior lobe, labeled terminals were numerous only in sublobule C of the ipsilateral paramedian lobule (2.7-4.9%). The projection fields in the horizontal plane of the lobules were reconstructed ...Continue Reading

Mentioned in this Paper

Alpha-Peroxidase
Wheat Germ Agglutinin Isolectin 2
Spinal Cord
Cerebellum
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Afferent Pathways
Felis catus

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