Oct 1, 1989

Spinocerebellar projections from spinal border cells in the cat as studied by anterograde transport of wheat germ agglutinin-horseradish peroxidase

The Journal of Comparative Neurology
M Matsushita, H Yaginuma


The cerebellar projections of spinal border cells, which give rise to crossed ascending axons, were studied in the lower lumbar segments by the anterograde transport of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) in the cat. Prior to the injections, the spinal cord was lesioned rostral and ipsilateral to the WGA-HRP injections to eliminate labeling of the ipsilaterally ascending axons. Following injections of WGA-HRP into the L4-L6 segments, labeled terminals were seen in sublobules Ib-Vf of the anterior lobe, sublobules VIf-VIe, lobule VIII, the paramedian lobule, and crus II. More than 90% of the total number of labeled terminals were in the anterior lobe; the projections were predominantly ipsilateral to their cells of origin (about 90% or more labeled terminals of the total number in each of sublobules IIb-Va). Many labeled terminals were seen ipsilaterally in sublobules IIb (11.1-17.5% of the total number), IIIa (11.7-12.9%), IIIb (16.1-17.6%), IVa (8.8-10.8%), IVb (6.2-10.5%), and Va (9.7-10.3%). In the posterior lobe, labeled terminals were numerous only in sublobule C of the ipsilateral paramedian lobule (2.7-4.9%). The projection fields in the horizontal plane of the lobules were reconstructed ...Continue Reading

Mentioned in this Paper

Wheat Germ Agglutinin Isolectin 2
Spinal Cord
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Afferent Pathways
Felis catus

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.