Spinonin, a novel glycoside from Ononis spinosa subsp. leiosperma

Journal of Natural Products
S KirmizigülC Bozok-Johansson

Abstract

The roots of Ononis spinosa subsp. leiosperma (Leguminosae) afforded a new glycoside, spinonin (1), possessing a novel skeleton, in addition to the known isoflavonoid glycoside, ononin [7beta-(glucosyloxy)formononetin] (2) and the known pterocarpan, 7-demethoxy-7-D-(glucosyloxy)homopterocarpin (3). The structure of the new isolate was elucidated by spectral methods including 1H and 13C NMR, COSY, APT, HETCOR, HMBC, NOESY, CD, FABMS, HRMS, EIMS, CIMS, and some chemical reactions. Spinonin was inactive against a number of human cancer cell lines and HIV-1 reverse transcriptase. The compounds 1 and 3 showed weak activity against Pseudomonas aeruginosa, whereas 2 was active against beta-hemolytic Streptococcus.

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Citations

Jun 15, 2007·Chemical Communications : Chem Comm·Charles M MarsonDavid T Davies
Nov 9, 2018·Journal of Mass Spectrometry : JMS·Nóra GampeSzabolcs Béni
May 14, 2017·Antonie van Leeuwenhoek·Sylwia Wdowiak-WróbelWanda Małek
Apr 14, 2011·Organic & Biomolecular Chemistry·Benito AlcaideJosé Miguel Alonso
Mar 2, 2010·The Journal of Organic Chemistry·Masahiro EgiShuji Akai
Apr 22, 2021·Journal of Asian Natural Products Research·Musa H Abu ZargaAmal M F Al-Aboudi

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