Spinosin, a C-Glucosylflavone, from Zizyphus jujuba var. spinosa Ameliorates Aβ1-42 Oligomer-Induced Memory Impairment in Mice

Biomolecules & Therapeutics
Sang Yoon KoJong Hoon Ryu

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder associated with progressive memory loss and neuronal cell death. Although numerous previous studies have been focused on disease progression or reverse pathological symptoms, therapeutic strategies for AD are limited. Alternatively, the identification of traditional herbal medicines or their active compounds has received much attention. The aims of the present study were to characterize the ameliorating effects of spinosin, a C-glucosylflavone isolated from Zizyphus jujuba var. spinosa, on memory impairment or the pathological changes induced through amyloid-β1-42 oligomer (AβO) in mice. Memory impairment was induced by intracerebroventricular injection of AβO (50 μM) and spinosin (5, 10, and 20 mg/kg) was administered for 7 days. In the behavioral tasks, the subchronic administration of spinosin (20 mg/kg, p.o.) significantly ameliorated AβO-induced cognitive impairment in the passive avoidance task or the Y-maze task. To identify the effects of spinosin on the pathological changes induced through AβO, immunohistochemistry and Western blot analyses were performed. Spinosin treatment also reduced the number of activated microglia and astrocytes observed after AβO injectio...Continue Reading

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Citations

Jan 28, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiaotong ZhaoJunbo Xie
Jan 24, 2017·Phytotherapy Research : PTR·Jin Gyu ChoiMyung Sook Oh
Jun 27, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Siu W TangBrian E Leonard
Dec 4, 2019·Biomolecules & Therapeutics·Xiaoying ZhangYing Jia
Jan 7, 2020·Current Neuropharmacology·Elzbieta RebasLudmila Zylinska
Feb 9, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Biqian FuYanhui Wang
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ioannis BakoyiannisDespina Perrea
Apr 13, 2021·Nutrition Research and Practice·Min Jeong KimHyun Young Kim
Aug 23, 2019·Aging and Disease·Seong Gak JeonMinho Moon

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